ARTICANZ - Beta (ver 0.91)
Annotated Registry of Trials in Cancer, Australia and New Zealand Ed.
- Results - catype/haematology/plasma-cell-dyscrasias/multiple-myeloma
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ARTICANZ provides informational content about cancer drug trials in Australia/NZ that is updated weekly but may not be completely accurate, and should not replace medical advice from qualified healthcare professionals. The platform is intended to be useful, providing information "as is" without warranties. Non-medical users must always consult healthcare providers for all clinical decisions.
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Plasma cell dyscrasias / Multiple myeloma
17
trial(s) found.
ACTRN12625001031459
Haem
Phase 2
Not yet recruiting
Place-of-care manufactured anti-BCMA chimeric antigen receptor (CAR) T-cells (ARI0002h) in patients with relapsed/refractory multiple myeloma.
Cyclophosphamide
Fludarabine
alkylating agent
antimetabolite
cancer therapy
cytotoxic chemotherapy
Multiple myeloma
WA
6000 - Perth - Royal Perth Hospital
ACTRN12625000438459
Haem
Phase 2
Recruiting
A Centralized Platform study for Functional High Risk Multiple Myeloma: Domain 1 - Talquetamab and Teclistamab (
ZEPFHR-MM-Domain-1
)
bispecific T-cell engager,BCMA-targeting
bispecific T-cell engager,GPRC5D-targeting
Multiple myeloma
NSW
2050 - Camperdown - Chris O'Brien Lifehouse
2139 - Concord - Concord Repatriation General Hospital
VIC
3004 - Melbourne, Southbank - Alfred Health
3084 - Heidelberg - Austin Hospital Olivia Newton-John Cancer Centre
3128 - Box Hill - Box Hill Hospital - Eastern Health
3220 - Geelong - Andrew Love Cancer Centre, University Hospital Geelong
QLD
4006 - Herston - The Royal Brisbane and Women's Hospital Cancer Centre
4102 - Woolloongabba - Princess Alexandra Hospital
WA
6009 - Nedlands - Sir Charles Gairdner Hospital - WA Cancer Centre
ACTRN12625000429459
Haem
Phase 2
Recruiting
A Centralized Platform study for Functional High Risk Multiple Myeloma - Master Protocol (
ZEPFHR-MM
)
Multiple myeloma
NSW
2050 - Camperdown - Chris O'Brien Lifehouse
2139 - Concord - Concord Repatriation General Hospital
2170 - Liverpool - Liverpool Hospital
2298 - Waratah - Calvary Mater Newcastle Medical Oncology
VIC
3004 - Melbourne, Southbank - Alfred Health
3128 - Box Hill - Box Hill Hospital - Eastern Health
3220 - Geelong - Andrew Love Cancer Centre, University Hospital Geelong
QLD
4102 - Woolloongabba - Princess Alexandra Hospital
ACTRN12625000056493
Haem
Phase 1
Not yet recruiting
Microbiome and Fibre Supplementation in Chimeric Antigen Receptor T cell Therapy patients - phase I clinical trial of safety and feasibility of oral fibre supplementation in CAR T (
Micro-Fibre-CAR
)
Leukaemia
Lymphoma
Multiple myeloma
ACTRN12624001468516
Haem
Phase 2
Not yet recruiting
A phase 2 study of the feasibility and efficacy of at home patient administered subcutaneous daratumumab in patients with relapsed multiple myeloma (
Dara@Home
)
anti-CD38 monoclonal antibody
Multiple myeloma
ACTRN12624000027516
Haem
Phase 2
Recruiting
Romosozumab for Patients with Multiple Myeloma with Skeletal Events on Zoledronic Acid: A Pilot Study
anti-SOST monoclonal antibody
bisphosphonate
Multiple myeloma
NSW
2010 - Darlinghurst - St Vincent's Hospital Sydney - The Kinghorn Cancer Centre
ACTRN12622001366741
Haem
Phase 2
Recruiting
Investigating the efficacy of Risk Directed front-line therapy for Multiple Myeloma incorporating Selinexor: The
RIDDLE-M-X
trial
XPO1 inhibitor
Multiple myeloma
NSW
2050 - Camperdown - Chris O'Brien Lifehouse
2640 - Albury - Border Medical Oncology Research Unit
2747 - Kingswood - Nepean Hospital - Nepean Cancer Care Centre
VIC
3004 - Melbourne, Southbank - Alfred Health
3066 - Epping - Northern Hospital
QLD
4006 - Herston - The Royal Brisbane and Women's Hospital Cancer Centre
4575 - Birtinya - Sunshine Coast University Hospital
ACTRN12622001158752
Haem
Phase 1 / Phase 2
Recruiting
MM25: A phase 1b/II study of the efficacy of Venetoclax, Iberdomide and Dexamethasone (IberVenD) for patients in first or second relapse of Multiple Myeloma with t(11;14) (
ALLG-Viber-M-MM25
)
Bcl2 inhibitor
CELMoD agent
glucocorticoid
Multiple myeloma
ACTRN12622000856718
Haem
Phase 1 / Phase 2
Not yet recruiting
A Phase 1/2, First-in-Human, Multicenter, Open-Label, Dose Escalation and Dose-Expansion Study assessing safety and tolerability of Single-Agent ISB 1442 in Patients with Relapsed/Refractory Multiple Myeloma (
ISB-1442-101
)
bispecific CD38/CD47 antibody
Multiple myeloma
NSW
2050 - Camperdown - Chris O'Brien Lifehouse
VIC
3004 - Melbourne, Southbank - Alfred Health
3066 - Epping - Northern Hospital
QLD
4215 - Southport - Gold Coast University Hospital
4217 - Benowa - Pindara Private Hospital
WA
6009 - Nedlands - Sir Charles Gairdner Hospital - WA Cancer Centre
TAS
7000 - Hobart - Royal Hobart Hospital
ACTRN12622000308796
Haem
Phase 1
Recruiting
A phase 1 study to assess the safety of short-course treatment with venetoclax prior to non-myeloablative stem cell transplantation for patients with haematological malignancies. (
VICTORY-study
)
Bcl2 inhibitor
Chronic lymphocytic leukaemia
Leukaemia
Lymphoma
Multiple myeloma
Myelodysplastic syndrome
Non-Hodgkin's lymphoma
VIC
3000 - Melbourne - Peter MacCallum Cancer Centre
3053 - Parkville - The Royal Women's Hospital and Institute of Maternal and Child Health
ACTRN12621001458820
Haem
Phase 1
Not yet recruiting
Phase I Clinical Trial to Determine Dosing Schedule of Hydroxychloroquine in Participants with Multiple Myeloma and Partial Response or Less to Carfilzomib (
CHARMM
)
anti-malarial agent
proteasome inhibitor
Cancer
Multiple myeloma
NSW
2170 - Liverpool - Liverpool Hospital
ACTRN12621001361897
Haem
Phase 2
Not yet recruiting
A single arm, open-label study of efficacy and safety of the Exportin 1 inhibitor selinexor in relapsed/refractory CNS Lymphoma and in relapsed/refractory CNS Myeloma (
EXCLAIM
)
XPO1 inhibitor
Diffuse large B-cell lymphoma
Multiple myeloma
VIC
3004 - Melbourne, Southbank - Alfred Health
3066 - Epping - Northern Hospital
ACTRN12611000605998
Haem
Phase 2
Recruiting
A Phase II trial of bortezomib and dexamethasone in renally-impaired patients with untreated multiple myeloma. (
The-BRIM-Trial
)
glucocorticoid
proteasome inhibitor
Multiple myeloma
ACTRN12610000700033
Haem
Phase 2
Recruiting
This is a Phase II, Open-label, Multi-Dose Study of the Monoclonal Antibody MDX-1097 to determine the efficacy of the antibody in patients who have received prior treatment for myeloma and have kappa light chain restricted multiple myeloma with stable measurable disease.
Multiple myeloma
ACTRN12609000116224
Haem
Phase 1 / Phase 2
Not yet recruiting
A pilot study investigating the combination of Mozobil® plus Neulasta® for Hematopoietic progenitor Cell (HPC-A) Mobilization in Patients with Lymphoma or Multiple Myeloma
Filgrastim
Pegfilgrastim
Lymphoma
Multiple myeloma
ACTRN12608000336381
Haem
Phase 1
Recruiting
An Open-label Phase I Study of the Safety and Efficacy of MDX-1097, an human IgG1k chimeric monoclonal antibody, in the Treatment of Previously Treated Kappa Light Chain Restricted Multiple Myeloma Patients with Stable Measurable Disease to determine the Safety, Tolerability and Maximum Tolerated Dose
Multiple myeloma
ACTRN12606000433505
Haem
Phase 1 / Phase 2
Not yet recruiting
A Three-Stage Phase I/II Dose-Escalation Study of High-Dose Melphalan with Palifermin for Patients with Multiple Myeloma to Determine a New Maximum Tolerated Dose (MTD) of Melphalan for use in Autografting (
ALLG
)
alkylating agent
Multiple myeloma
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Recruitment Status
Recruiting (9)
Not yet recruiting (8)
Recruitment Country and State
NSW (6)
VIC (6)
QLD (4)
WA (3)
TAS (1)
Phase
Phase 1 (4)
Phase 1 / Phase 2 (4)
Phase 2 (9)
Trial Type
Haem (17)
Cancer Therapy Class
proteasome
24%
CD38
12%
XPO1
12%
cereblon
12%
Bcl2
12%
BCMA
6%
GPRC5D
6%
SOST
6%
CD47
6%
Facility
3004 - Melbourne, Southbank - Alfred Health (5)
2050 - Camperdown - Chris O'Brien Lifehouse (4)
3066 - Epping - Northern Hospital (3)
2139 - Concord - Concord Repatriation General Hospital (2)
3128 - Box Hill - Box Hill Hospital - Eastern Health (2)
3220 - Geelong - Andrew Love Cancer Centre, University Hospital Geelong (2)
4006 - Herston - The Royal Brisbane and Women's Hospital Cancer Centre (2)
4102 - Woolloongabba - Princess Alexandra Hospital (2)
6009 - Nedlands - Sir Charles Gairdner Hospital - WA Cancer Centre (2)
2170 - Liverpool - Liverpool Hospital (2)
6000 - Perth - Royal Perth Hospital (1)
3084 - Heidelberg - Austin Hospital Olivia Newton-John Cancer Centre (1)
2298 - Waratah - Calvary Mater Newcastle Medical Oncology (1)
2010 - Darlinghurst - St Vincent's Hospital Sydney - The Kinghorn Cancer Centre (1)
2640 - Albury - Border Medical Oncology Research Unit (1)
2747 - Kingswood - Nepean Hospital - Nepean Cancer Care Centre (1)
4575 - Birtinya - Sunshine Coast University Hospital (1)
4215 - Southport - Gold Coast University Hospital (1)
4217 - Benowa - Pindara Private Hospital (1)
7000 - Hobart - Royal Hobart Hospital (1)
3000 - Melbourne - Peter MacCallum Cancer Centre (1)
3053 - Parkville - The Royal Women's Hospital and Institute of Maternal and Child Health (1)
Cancer Type
Cancer
Haematological malignancy
Multiple myeloma
Plasma cell disorder
Lymphoma
Leukaemia
B-cell malignancy
Mature B-cell malignancy
Non-Hodgkin's lymphoma
Chronic lymphocytic leukaemia
Lymphoid leukaemia
Myelodysplastic syndrome
Myeloproliferative neoplasm
B-cell lymphoma
Diffuse large B-cell lymphoma
High-grade B-cell lymphoma
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