ARTICANZ - Beta (ver 0.9)
Annotated Registry of Trials in Cancer, Australia and New Zealand Ed.
- Results - catype/medical-oncology/mesothelioma/advanced-metastatic
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ARTICANZ provides informational content about cancer drug trials in Australia/NZ that is updated weekly but may not be completely accurate, and should not replace medical advice from qualified healthcare professionals. The platform is intended to be useful, providing information "as is" without warranties. Non-medical users must always consult healthcare providers for all clinical decisions.
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Respiratory / Mesothelioma - Advanced/metastatic
11
trial(s) found.
NCT06097728
Advanced
Phase 3
Recruiting
A Phase III, Randomized, Open-Label, Multicenter, Global Study of Volrustomig (MEDI5752) in Combination With Carboplatin Plus Pemetrexed Versus Platinum Plus Pemetrexed or Nivolumab Plus Ipilimumab in Participants With Unresectable Pleural Mesothelioma (
eVOLVE-Meso
)
anti-CTLA-4 monoclonal antibody
anti-PD-1 monoclonal antibody
antimetabolite
bispecific PD-L1/CTLA4 antibody
platinum-based antineoplastic agent
Pleural mesothelioma
NSW
2145 - Westmead - The Crown Princess Mary Cancer Centre - Westmead Hospital
VIC
3000 - Melbourne - Peter MacCallum Cancer Centre
3168 - Clayton - Monash Medical Centre
QLD
4032 - Chermside - The Prince Charles Hospital
WA
6009 - Nedlands - Sir Charles Gairdner Hospital - WA Cancer Centre
NCT05498597
Advanced
Phase 1
Recruiting
First-in-Human, Phase 1 Study of AMT-151, an Anti-Folate Receptor Alpha Antibody-Drug Conjugate, in Patients With Selected Advanced Solid Tumours (
AMT-151-01
)
anti-FR-alpha antibody-drug conjugate
Adenocarcinoma
Cancer
Carcinoma
Endometrial cancer
Endometrial clear cell carcinoma
Endometrial endometrioid carcinoma
Lung adenocarcinoma
Ovarian cancer
Ovarian clear cell carcinoma
Ovarian endometrioid adenocarcinoma
Pancreatic adenocarcinoma
Pleural mesothelioma
Solid tumour
Triple-negative breast cancer
Uterine serous carcinoma
NSW
2050 - Camperdown - Chris O'Brien Lifehouse
VIC
3144 - Malvern - Cabrini Health, Cabrini Cancer Care Centre
QLD
4101 - South Brisbane - Mater Hospital Brisbane / ICON Cancer Centre
SA
5000 - Adelaide - Royal Adelaide Hospital - Adelaide Cancer Centre
WA
6009 - Nedlands - One Clinical Research
NCT05086692
Advanced
Phase 1 / Phase 2
Recruiting
A Phase 1/2 Open Label, Dose Escalation and Expansion Study of MDNA11, IL-2 Superkine, Administered Alone or in Combination With Immune Checkpoint Inhibitor in Patients With Advanced Solid Tumors (
ABILITY-1
)
IL-2 superkine
Acral lentiginous melanoma
Bladder cancer
Cancer
Cervical cancer
Clear cell renal cell carcinoma
Colorectal cancer
Cutaneous basal cell carcinoma
Cutaneous melanoma
Cutaneous squamous cell carcinoma
Endometrial carcinoma
Epithelial Ovarian Cancer
Fallopian tube cancer
Gastric cancer
Gastroesophageal junction adenocarcinoma
Head and neck squamous cell carcinoma
Melanoma
Merkel cell carcinoma
Mucosal melanoma
Non-melanoma skin cancer
Non-squamous non-small-cell lung cancer
Oesophageal cancer
Ovarian cancer
Pancreatic adenocarcinoma
Pleural mesothelioma
Primary peritoneal serous carcinoma
Skin cancer
Solid tumour
Squamous non-small-cell lung cancer
Triple-negative breast cancer
dMMR solid cancer
NSW
2031 - Randwick - Scientia Clinical Research Ltd
2109 - North Ryde - Macquarie University Hospital
QLD
4120 - Greenslopes - Greenslopes Private Hospital- Gallipoli Medical Research Foundation
NCT04857372
Advanced
Phase 1
Recruiting
An Open-label, Multi-center, Phase I Study of Oral IAG933 in Adult Patients With Advanced Mesothelioma and Other Solid Tumors (
CIAG933A12101
)
YAP-TEAD inhibitor
Mesothelioma
Solid tumour
VIC
3000 - Melbourne - Peter MacCallum Cancer Centre
NCT04665206
Advanced
Phase 1
Recruiting
Phase 1, Multi-Center, Open-Label Study of VT3989, Alone or in Combination, in Patients with Refractory Locally Advanced or Metastatic Solid Tumors (
VT3989-001
)
TEAD palmitoylation inhibitor
Mesothelioma
Non-small cell lung cancer
Solid tumour
VIC
3000 - Melbourne - Peter MacCallum Cancer Centre
3168 - Clayton - Monash Medical Centre
WA
6009 - Nedlands - Linear Clinical Research
NCT02628067
Advanced
Phase 2
Recruiting
A Clinical Trial of Pembrolizumab (MK-3475) Evaluating Predictive Biomarkers in Subjects With Advanced Solid Tumors (KEYNOTE 158) (
KEYNOTE-158
)
anti-PD-1 monoclonal antibody
Anal cancer
Biliary tract cancer
Cancer
Cervical cancer
Cholangiocarcinoma
Colorectal cancer
Endometrial cancer
Endometrial carcinoma
Lung carcinoid tumour
Mesothelioma
Neuroendocrine tumour
Pancreatic neuroendocrine tumour
Salivary gland cancer
Salivary gland carcinoma
Small-cell lung cancer
Solid tumour
Thyroid cancer
Vulval cancer
NSW
2109 - North Ryde - Macquarie University Hospital
ACTRN12625000203459
Advanced
Phase 1 / Phase 2
Not yet recruiting
An open-label, multicenter, Phase I/IIa study assessing the safety and efficacy of EGFR targeted EDVsTM carrying cytotoxic drug PNU-159682 plus concurrent immunomodulatory adjuvant non-targeted EDVs carrying a-galactosyl ceramide in subjects with advanced EGFR-expressing cancers who have failed second-line therapy or where first- and/or second-line therapy is not appropriate (EGFR EDV-D682/GC Trial) (
ENG19
)
EnGeneIC Dream Vector-nanocells-delivered,EGFR-targeting
Colorectal cancer
Kidney cancer
Lung cancer
Mesothelioma
Non-small cell lung cancer
Pancreatic adenocarcinoma
Solid tumour
Triple-negative breast cancer
NSW
2060 - North Sydney - Mater Hospital
VIC
3199 - Frankston - Peninsula Health Frankston Hospital
ACTRN12624000268549
Advanced
Phase 1
Not yet recruiting
LEPO
: A phase 1 study of Leptospermum petersonii extract for patients with mesothelioma
Mesothelioma
ACTRN12614001248651
Advanced
Phase 1
Recruiting
MesomiR 1: A Phase I study of intravenously administered Epidermal Growth Factor Receptor (EGFR)-targeted, EnGeneIC Delivery Vehicle (EDV)-packaged, miR-16 mimic (TargomiRs) for patients with Malignant Pleural Mesothelioma (MPM) and advanced Non-Small Cell Lung Cancer (NSCLC) failing on standard therapy (
MesomiR-1
)
miR-16 miRNA mimic
Non-small cell lung cancer
Pleural mesothelioma
NSW
2050 - Camperdown - Chris O'Brien Lifehouse
2065 - St Leonards - Northern Sydney Cancer Centre, Royal North Shore Hospital
2139 - Concord - Concord Repatriation General Hospital
NCT05500508
Advanced
Phase 1 / Phase 2
Terminated
A Phase 1B/2A Study of the Safety, Tolerability and Initial Efficacy of Oral AMXT 1501 Dicaprate and Intravenous Difluoromethylornithine (DFMO) in Patients With Cancer (
AMXT1501-102
)
polyamine transport inhibitor
Breast cancer
Cancer
Central nervous system cancer
Cervical cancer
Colorectal cancer
Endometrial cancer
Gastric cancer
H3K27M-mutant glioma
Head and neck cancer
Malignant glioma
Melanoma
Mesothelioma
Non-small cell lung cancer
Oesophageal cancer
Ovarian cancer
Papillary thyroid cancer
Pleural mesothelioma
Solid tumour
NSW
2145 - Westmead - The Children's Hospital at Westmead
NCT05228015
Advanced
Phase 1
Terminated
A Phase 1, First-in-Human Study of IK-930, an Oral TEAD Inhibitor Targeting the Hippo Pathway in Subjects with Advanced Solid Tumors (
IK930-001
)
YAP-TEAD inhibitor
Epithelioid haemangioendothelioma
Mesothelioma
Pleural mesothelioma
Solid tumour
VIC
3199 - Frankston - Peninsula Health Frankston Hospital
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Recruitment Status
Recruiting (7)
Not yet recruiting (2)
Terminated (2)
Recruitment Country and State
NSW (7)
VIC (6)
QLD (3)
WA (3)
SA (1)
Phase
Phase 1 (6)
Phase 1 / Phase 2 (3)
Phase 2 (1)
Phase 3 (1)
Trial Type
Advanced (11)
Cancer Therapy Class
PD-1
36%
PD-1/PD-L1
36%
YAP-TEAD
27%
EGFR
27%
CTLA4
18%
PD-L1
9%
FR-alpha
9%
IL-2
9%
polyamine transport
9%
Facility
3000 - Melbourne - Peter MacCallum Cancer Centre (3)
3168 - Clayton - Monash Medical Centre (2)
2050 - Camperdown - Chris O'Brien Lifehouse (2)
2109 - North Ryde - Macquarie University Hospital (2)
3199 - Frankston - Peninsula Health Frankston Hospital (2)
2145 - Westmead - The Crown Princess Mary Cancer Centre - Westmead Hospital (1)
4032 - Chermside - The Prince Charles Hospital (1)
6009 - Nedlands - Sir Charles Gairdner Hospital - WA Cancer Centre (1)
3144 - Malvern - Cabrini Health, Cabrini Cancer Care Centre (1)
4101 - South Brisbane - Mater Hospital Brisbane / ICON Cancer Centre (1)
5000 - Adelaide - Royal Adelaide Hospital - Adelaide Cancer Centre (1)
6009 - Nedlands - One Clinical Research (1)
2031 - Randwick - Scientia Clinical Research Ltd (1)
4120 - Greenslopes - Greenslopes Private Hospital- Gallipoli Medical Research Foundation (1)
6009 - Nedlands - Linear Clinical Research (1)
2060 - North Sydney - Mater Hospital (1)
2065 - St Leonards - Northern Sydney Cancer Centre, Royal North Shore Hospital (1)
2139 - Concord - Concord Repatriation General Hospital (1)
2145 - Westmead - The Children's Hospital at Westmead (1)
Cancer Type
Cancer
Mesothelioma
Solid tumour
Thoracic cancer
Lung cancer
Respiratory tract cancer
Pleural mesothelioma
Non-small cell lung cancer
Gastrointestinal cancer
Upper gastrointestinal cancer
Breast cancer
Endometrial cancer
Gynaecological cancer
Pancreatic cancer
Pancreatobiliary cancer
Colorectal cancer
Lower gastrointestinal cancer
Breast adenocarcinoma
Endometrial carcinoma
Exocrine pancreatic cancer
Ovarian cancer
Pancreatic adenocarcinoma
Triple-negative breast cancer
Cervical cancer
HPV-related cancer
HPV16-positive cancer
Head and neck cancer
Viral-related cancer
Carcinoma
Epithelial Ovarian Cancer
Non-squamous non-small-cell lung cancer
Gastric cancer
Gastroesophageal cancer
Kidney cancer
Melanoma
Oesophageal cancer
Urogenital cancer
Endocrine gland cancer
Thyroid cancer
Adenocarcinoma
Endometrial adenocarcinoma
Endometrial clear cell carcinoma
Endometrial endometrioid carcinoma
Lung adenocarcinoma
Ovarian adenocarcinoma
Ovarian clear cell carcinoma
Ovarian endometrioid adenocarcinoma
Uterine serous carcinoma
Acral lentiginous melanoma
Biomarker-defined solid tumour
Bladder cancer
Clear cell renal cell carcinoma
Cutaneous basal cell carcinoma
Cutaneous melanoma
Cutaneous squamous cell carcinoma
Fallopian tube cancer
Gastric carcinoma
Gastroesophageal junction adenocarcinoma
Head and neck squamous cell carcinoma
High-grade serous carcinoma of the ovary, fallopian tube, and peritoneum
MSI-H/dMMR solid tumour
Merkel cell carcinoma
Mucosal melanoma
Non-melanoma skin cancer
Peritoneal cancer
Primary peritoneal serous carcinoma
Skin cancer
Squamous non-small-cell lung cancer
dMMR solid cancer
Anal cancer
Biliary tract cancer
Cholangiocarcinoma
Gastro-entero-pancreatic neuroendocrine tumour
Hepatobiliary cancer
Lung carcinoid tumour
Neuroendocrine carcinoma
Neuroendocrine tumour
Pancreatic neuroendocrine tumour
Salivary gland cancer
Salivary gland carcinoma
Small-cell lung cancer
Small-cell neuroendocrine carcinoma
Vaginal and vulvar cancer
Vulval cancer
Central nervous system cancer
Differentiated thyroid carcinoma
Glioma
H3K27M-mutant glioma
High-grade glioma
Malignant glioma
Neurological cancer
Papillary thyroid cancer
Epithelioid haemangioendothelioma
Sarcoma
Soft tissue sarcoma
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