ARTICANZ - Beta (ver 0.91)
Annotated Registry of Trials in Cancer, Australia and New Zealand Ed.
- Results - catype/paediatric-and-aya/neurological
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ARTICANZ provides informational content about cancer drug trials in Australia/NZ that is updated weekly but may not be completely accurate, and should not replace medical advice from qualified healthcare professionals. The platform is intended to be useful, providing information "as is" without warranties. Non-medical users must always consult healthcare providers for all clinical decisions.
Search results
Neurological
15
trial(s) found.
NCT07334301
Paed
Phase 1 / Phase 2
Recruiting
A Multi-Arm, Multi-Stage Platform Trial For Relapsed Neuroblastoma (
BEACON2
)
Bevacizumab
Dinutuximab
Irinotecan
Temozolomide
Topotecan
alkylating agent
anti-GD2 monoclonal antibody
anti-VEGF monoclonal antibody
cancer therapy
cancer therapy,GD2-targeting
cancer therapy,VEGF-targeting
cytotoxic chemotherapy
immuno-oncology therapy,GD2-targeting
immuno-oncology therapy,VEGF-targeting
topoisomerase inhibitor
Neuroblastoma
NSW
2031 - Randwick - Sydney Children's Hospital
NZ
NZ.1023 - Grafton - Starship Children's Hospital
NCT07286292
Paed
Phase 2
Recruiting
A Phase 2, Single Arm, Open-label Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Vorasidenib in Pediatric Participants Aged 12 to < 18 Years Old With Grade 2 Astrocytoma or Oligodendroglioma With an IDH1 or IDH2 Mutation (
S095032-236
)
IDH1/IDH2 mutant selective inhibitor
Astrocytoma
Oligodendroglioma
NSW
2031 - Randwick - Sydney Children's Hospital
NCT06838676
Paed
Phase 2
Recruiting
A Phase II Trial of ACT001 in Children and Adolescents With Diffuse Intrinsic Pontine Gliomas and H3K27-altered High Grade Gliomas (
CONNECT2110
)
NFKB inhibitor
Diffuse intrinsic pontine glioma
High-grade glioma
NSW
2031 - Randwick - Sydney Children's Hospital
VIC
3053 - Parkville - The Royal Women's Hospital and Institute of Maternal and Child Health
QLD
4101 - South Brisbane - Queensland Children's Hospital
WA
6009 - Perth - Perth Children's Hospital
NZ
NZ.1023 - Grafton - Starship Children's Hospital
NCT06395103
Paed
Phase 1 / Phase 2
Recruiting
LIGHTBEAM-U01 Substudy 01A: A Phase 1/2 Substudy to Evaluate the Safety and Efficacy of Zilovertamab Vedotin in Pediatric and Young Adult Participants With Hematologic Malignancies or Solid Tumors (
9999-01A
)
anti-ROR1 antibody-drug conjugate
B-cell acute lymphoblastic leukaemia/lymphoma
Burkitt lymphoma
Diffuse large B-cell lymphoma
Ewing sarcoma
Neuroblastoma
NSW
2031 - Randwick - Sydney Children's Hospital
VIC
3052 - Parkville - Royal Children's Hospital Melbourne
QLD
4101 - South Brisbane - Queensland Children's Hospital
NCT06333899
Paed
Phase 1
Recruiting
A Pilot Study of Lorlatinib for Treatment of Children With Newly Diagnosed High-Grade Glioma With ROS-1 (ROS Proto-Oncogene 1, Receptor Tyrosine Kinase) or ALK (Anaplastic Lymphoma Kinase) Fusion (
CONNECT-TarGeT-L
)
ALK inhibitor,third generation
ROS1 inhibitor
Anaplastic astrocytoma
Diffuse intrinsic pontine glioma
Diffuse midline glioma
Glioblastoma
Glioma
High-grade glioma
NSW
2031 - Randwick - Sydney Children's Hospital
QLD
4101 - South Brisbane - Queensland Children's Hospital
WA
6009 - Perth - Perth Children's Hospital
NZ
NZ.1023 - Grafton - Starship Children's Hospital
NCT06208657
Paed
Phase 1 / Phase 2
Recruiting
Optimal Precision TherapIes to CustoMISE Care in Childhood and Adolescent Cancer (
OPTIMISE
)
Irinotecan
Nivolumab
PI3K alpha inhibitor
PI3K delta inhibitor
PI3K inhibitor
Paxalisib
Relatlimab
Temozolomide
alkylating agent
anti-LAG3 monoclonal antibody
anti-PD-1 monoclonal antibody
cancer therapy
cancer therapy,LAG3-targeting
cancer therapy,PD-1-targeting
cancer therapy,PD-1/PD-L1-targeting
cancer therapy,PI3K-targeting
cancer therapy,PI3K delta-targeting
cancer therapy,PI3Kalpha-targeting
cancer therapy,mTOR-targeting
cancer therapy,mTORC1-targeting
cancer therapy,mTORC2-targeting
cytotoxic chemotherapy
dual PI3K/mTOR inhibitor
immune checkpoint blockade
immune checkpoint blockade,LAG3-targeting
immune checkpoint blockade,PD-1-targeting
immuno-oncology therapy,LAG3-targeting
immuno-oncology therapy,PD-1-targeting
mTORC1/mTORC2 inhibitor
mTORC1 inhibitor
mTORC2 inhibitor
mTOR inhibitor
topoisomerase inhibitor
Cancer
Central nervous system cancer
Solid tumour
NSW
2031 - Randwick - Sydney Children's Hospital
2145 - Westmead - The Children's Hospital at Westmead
2305 - New Lambton Heights - John Hunter Children's Hospital
VIC
3052 - Parkville - Royal Children's Hospital Melbourne
3168 - Clayton - Monash Children's Hospital
QLD
4101 - South Brisbane - Queensland Children's Hospital
SA
5006 - North Adelaide - Women's and Children's Hospital-Adelaide Cancer Centre
WA
6009 - Perth - Perth Children's Hospital
TAS
7000 - Hobart - Royal Hobart Hospital
NCT06161974
Paed
Phase 2
Recruiting
Phase 2 Study of Olutasidenib With Temozolomide as Maintenance Therapy in Pediatric and Young Adult Patients Newly Diagnosed With High-Grade Glioma (HGG), Including Diffuse Intrinsic Pontine Glioma (DIPG), Which Harbor IDH1 Mutations (
TarGeT-D
)
IDH1 R132 inhibitor
alkylating agent
Astrocytoma
Cancer
Central nervous system cancer
Diffuse intrinsic pontine glioma
Glioma
H3K27M-mutant glioma
High-grade glioma
Oligodendroglioma
NSW
2031 - Randwick - Sydney Children's Hospital
QLD
4101 - South Brisbane - Queensland Children's Hospital
WA
6009 - Perth - Perth Children's Hospital
NZ
NZ.1023 - Grafton - Starship Children's Hospital
NCT05843253
Paed
Phase 2
Recruiting
Phase 2 Study of Ribociclib-Containing Post-Radiotherapy Combinations in Pediatric and Young Adult Patients Newly Diagnosed With High-Grade Glioma, Including Diffuse Intrinsic Pontine Glioma: Ribociclib and Everolimus for HGG/DIPG Which Harbor Alterations of the Cell Cycle and/or PI3K/mTOR Pathways AND Ribociclib and Temozolomide for DHG, H3G34-mutant (
CONNECT-TarGeT-A
)
CDK4/6 inhibitor
alkylating agent
mTORC1 inhibitor
radiotherapy
Anaplastic astrocytoma
Central nervous system cancer
Diffuse hemispheric glioma
Diffuse intrinsic pontine glioma
Glioblastoma
Glioma
H3K27M-mutant glioma
High-grade glioma
NSW
2031 - Randwick - Sydney Children's Hospital
VIC
3053 - Parkville - The Royal Women's Hospital and Institute of Maternal and Child Health
QLD
4101 - South Brisbane - Queensland Children's Hospital
WA
6009 - Perth - Perth Children's Hospital
NZ
NZ.1023 - Grafton - Starship Children's Hospital
NCT05839379
Paed
Recruiting
Molecularly-Guided Phase II Umbrella Trial for Children, Adolescents, and Young Adults Newly Diagnosed With High-Grade Glioma, Including Diffuse Intrinsic Pontine Glioma (
CONNECT-TarGeT-SCR
)
Anaplastic astrocytoma
Central nervous system cancer
Diffuse intrinsic pontine glioma
Glioblastoma
Glioma
H3K27M-mutant glioma
High-grade glioma
NSW
2031 - Randwick - Sydney Children's Hospital
VIC
3053 - Parkville - The Royal Women's Hospital and Institute of Maternal and Child Health
QLD
4101 - South Brisbane - Queensland Children's Hospital
WA
6009 - Perth - Perth Children's Hospital
NZ
NZ.1023 - Grafton - Starship Children's Hospital
NCT05230758
Paed
Phase 3
Recruiting
Phase III Randomized Double-blind Placebo-controlled Trial of Metformin for Cognitive Recovery and White Matter Growth in Paediatric Patients With a Brain Tumour (
Met-Med-Can
)
biguanide antihyperglycaemic agent
placebo
Medulloblastoma
NSW
2145 - Westmead - The Children's Hospital at Westmead
2305 - New Lambton Heights - John Hunter Children's Hospital
VIC
3052 - Parkville - Royal Children's Hospital Melbourne
3168 - Clayton - Monash Children's Hospital
SA
5006 - North Adelaide - Women's and Children's Hospital-Adelaide Cancer Centre
WA
6009 - Perth - Perth Children's Hospital
NCT04870944
Paed
Phase 1 / Phase 2
Recruiting
A Phase 1/2 Trial of CBL0137 (NSC# 825802) in Patients With Relapsed or Refractory Solid Tumors Including CNS Tumors and Lymphoma (
PEPN2111
)
curaxin,FACT complex-targeting
Cancer
Central nervous system cancer
Diffuse intrinsic pontine glioma
Diffuse midline glioma
Lymphoma
Solid tumour
NSW
2031 - Randwick - Sydney Children's Hospital
NCT04775485
Paed
Phase 2
Recruiting
FIREFLY-1
: A Phase 2, Open-Label, Multicenter Study to Evaluate the Safety and Efficacy of the Oral Pan-RAF Inhibitor DAY101 in Pediatric Patients With RAF-Altered, Recurrent or Progressive Low-Grade Glioma and Advanced Solid Tumors
RAF inhibitor,type 2
Low-grade glioma
Solid tumour
NSW
2031 - Randwick - Sydney Children's Hospital
2145 - Westmead - The Children's Hospital at Westmead
VIC
3052 - Parkville - Royal Children's Hospital Melbourne
QLD
4101 - South Brisbane - Queensland Children's Hospital
WA
6009 - Perth - Perth Children's Hospital
NCT04655404
Paed
Phase 1
Recruiting
A Pilot and Surgical Study of Larotrectinib for Treatment of Children With Newly-Diagnosed High-Grade Glioma With NTRK Fusion (
CONNECT1903
)
TRK inhibitor,first generation
Diffuse intrinsic pontine glioma
High-grade glioma
NSW
2031 - Randwick - Sydney Children's Hospital
QLD
4101 - South Brisbane - Queensland Children's Hospital
WA
6009 - Perth - Perth Children's Hospital
NZ
NZ.1023 - Grafton - Starship Children's Hospital
NCT04094610
Paed
Phase 1 / Phase 2
Recruiting
A Phase 1/2, Open-Label, Safety, Tolerability, Pharmacokinetics, and Anti-Tumor Activity Study of Repotrectinib in Pediatric and Young Adult Subjects With Advanced or Metastatic Malignancies Harboring ALK, ROS1, NTRK1-3 Alterations (
CA127-1029
)
ALK inhibitor,third generation
ROS1 inhibitor
TRK inhibitor,second generation
Central nervous system cancer
Lymphoma
Solid tumour
NSW
2031 - Randwick - Sydney Children's Hospital
2145 - Westmead - The Children's Hospital at Westmead
QLD
4101 - South Brisbane - Queensland Children's Hospital
WA
6009 - Perth - Perth Children's Hospital
NCT03838042
Paed
Phase 1 / Phase 2
Recruiting
INFORM2 Exploratory Multinational Phase I/II Combination Study of Nivolumab and Entinostat in Children and Adolescents With Refractory High-risk Malignancies (INFORM2-NivEnt) (
Final4,-18-10-2023
)
HDAC inhibitor,class 1 selective
anti-PD-1 monoclonal antibody
Central nervous system cancer
Solid tumour
NSW
2031 - Randwick - Sydney Children's Hospital
2145 - Westmead - The Children's Hospital at Westmead
VIC
3052 - Parkville - Royal Children's Hospital Melbourne
WA
6009 - Perth - Perth Children's Hospital
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Recruitment Status
Recruiting (15)
Recruitment Country and State
NSW (15)
WA (11)
QLD (10)
VIC (8)
NZ (7)
SA (2)
TAS (1)
Phase
Phase 1 (2)
Phase 1 / Phase 2 (6)
Phase 2 (5)
Phase 3 (1)
Trial Type
Paed (15)
Paed (1)
Cancer Therapy Class
IDH1
13%
IDH1 R132
13%
ALK
13%
ROS1
13%
PD-1
13%
PD-1/PD-L1
13%
mTOR
13%
mTORC1
13%
TRK
13%
GD2
7%
VEGF
7%
IDH2
7%
IDH2 mutant selective
7%
NFKB
7%
ROR1
7%
DPD
7%
orotate phosphoribosyltransferase
7%
LAG3
7%
PI3K
7%
PI3K delta
7%
PI3Kalpha
7%
mTORC2
7%
CDK4
7%
CDK6
7%
FACT complex
7%
BRAF
7%
CRAF
7%
RAF
7%
HDAC
7%
Facility
2031 - Randwick - Sydney Children's Hospital (14)
6009 - Perth - Perth Children's Hospital (11)
4101 - South Brisbane - Queensland Children's Hospital (10)
NZ.1023 - Grafton - Starship Children's Hospital (7)
3052 - Parkville - Royal Children's Hospital Melbourne (5)
2145 - Westmead - The Children's Hospital at Westmead (5)
3053 - Parkville - The Royal Women's Hospital and Institute of Maternal and Child Health (3)
2305 - New Lambton Heights - John Hunter Children's Hospital (2)
3168 - Clayton - Monash Children's Hospital (2)
5006 - North Adelaide - Women's and Children's Hospital-Adelaide Cancer Centre (2)
7000 - Hobart - Royal Hobart Hospital (1)
Cancer Type
Cancer
Neurological cancer
Solid tumour
Central nervous system cancer
Glioma
Malignant glioma
Diffuse intrinsic pontine glioma
H3K27M-mutant glioma
High-grade glioma
Low-grade glioma
Haematological malignancy
Lymphoma
Anaplastic astrocytoma
Glioblastoma
Neuroblastic tumour
Neuroblastoma
Peripheral nervous system tumour
Astrocytoma
Oligodendroglioma
Ewing family of tumours
Sarcoma
Diffuse midline glioma
Acute lymphoblastic leukaemia
B-cell acute lymphoblastic leukaemia/lymphoma
B-cell lymphoma
B-cell malignancy
Bone cancer
Burkitt lymphoma
Diffuse large B-cell lymphoma
Ewing sarcoma
High-grade B-cell lymphoma
Leukaemia
Lymphoid leukaemia
Mature B-cell malignancy
Non-Hodgkin's lymphoma
Primitive neuroectodermal tumour
Diffuse hemispheric glioma
Central nervous system primitive neuroectodermal tumour
Medulloblastoma
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