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Annotated Registry of Trials in Cancer, Australia and New Zealand Ed.
- Results - catype/paediatric-and-aya/neurological/glioma/high-grade-glioma
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ARTICANZ provides informational content about cancer drug trials in Australia/NZ that is updated weekly but may not be completely accurate, and should not replace medical advice from qualified healthcare professionals. The platform is intended to be useful, providing information "as is" without warranties. Non-medical users must always consult healthcare providers for all clinical decisions.
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Neurological / Glioma - High-grade glioma
4
trial(s) found.
NCT05843253
Paed
Phase 2
Recruiting
Phase 2 Study of Ribociclib-Containing Post-Radiotherapy Combinations in Pediatric and Young Adult Patients Newly Diagnosed With High-Grade Glioma, Including Diffuse Intrinsic Pontine Glioma: Ribociclib and Everolimus for HGG/DIPG Which Harbor Alterations of the Cell Cycle and/or PI3K/mTOR Pathways AND Ribociclib and Temozolomide for DHG, H3G34-mutant (
CONNECT-TarGeT-A
)
CDK4/6 inhibitor
alkylating agent
mTORC1 inhibitor
radiotherapy
Anaplastic astrocytoma
Central nervous system cancer
Diffuse hemispheric glioma
Diffuse intrinsic pontine glioma
Glioblastoma
Glioma
H3K27M-mutant glioma
High-grade glioma
NSW
2031 - Randwick - Sydney Children's Hospital
VIC
3053 - Parkville - The Royal Women's Hospital and Institute of Maternal and Child Health
QLD
4101 - South Brisbane - Queensland Children's Hospital
WA
6009 - Perth - Perth Children's Hospital
NZ
NZ.1023 - Grafton - Starship Children's Hospital
NCT05839379
Paed
Recruiting
Molecularly-Guided Phase II Umbrella Trial for Children, Adolescents, and Young Adults Newly Diagnosed With High-Grade Glioma, Including Diffuse Intrinsic Pontine Glioma (
CONNECT-TarGeT-SCR
)
Anaplastic astrocytoma
Central nervous system cancer
Diffuse intrinsic pontine glioma
Glioblastoma
Glioma
H3K27M-mutant glioma
High-grade glioma
NSW
2031 - Randwick - Sydney Children's Hospital
VIC
3053 - Parkville - The Royal Women's Hospital and Institute of Maternal and Child Health
QLD
4101 - South Brisbane - Queensland Children's Hospital
WA
6009 - Perth - Perth Children's Hospital
NZ
NZ.1023 - Grafton - Starship Children's Hospital
NCT04323046
Paed
Phase 1
Recruiting
A Single Arm, Pilot of Neoadjuvant Checkpoint Inhibition Followed by Adjuvant Checkpoint Inhibition in Children and Young Adults With Recurrent or Progressive High Grade Glioma (HGG)
Nivolumab
anti-PD-1 monoclonal antibody
cancer therapy
cancer therapy,PD-1-targeting
cancer therapy,PD-1/PD-L1-targeting
immune checkpoint blockade
immune checkpoint blockade,PD-1-targeting
immuno-oncology therapy,PD-1-targeting
Glioblastoma
Glioma
Malignant glioma
NSW
2031 - Randwick - Sydney Children's Hospital
2145 - Westmead - The Children's Hospital at Westmead
VIC
3052 - Parkville - Royal Children's Hospital Melbourne
QLD
4101 - South Brisbane - Queensland Children's Hospital
SA
5006 - North Adelaide - Women's and Children's Hospital-Adelaide Cancer Centre
WA
6009 - Perth - Perth Children's Hospital
NCT03975829
Paed
Phase 4
Recruiting
An Open Label, Multi-center Roll-over Study to Assess Long-term Effect in Pediatric Patients Treated With Tafinlar (Dabrafenib) and/or Mekinist (Trametinib) (
CDRB436G2401
)
BRAF V600 inhibitor
MEK inhibitor
Anaplastic astrocytoma
Anaplastic ganglioglioma
Anaplastic oligodendroglioma
Anaplastic pleomorphic xanthoastrocytoma
Astrocytoma
Central neurocytoma
Desmoplastic infantile astrocytoma
Diffuse astrocytoma
Extra-ventricular Neurocytoma
Gangliocytoma
Ganglioglioma
Glioblastoma
Glioma
Liponeurocytoma
Neurofibromatosis
Oligodendroglioma
Papillary glioneuronal tumour
Pilocytic astrocytoma
Pleomorphic xanthoastrocytoma
Rosette-forming glioneuronal tumour
NSW
2010 - Darlinghurst - St Vincent's Hospital Sydney - The Kinghorn Cancer Centre
VIC
3052 - Parkville - Royal Children's Hospital Melbourne
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Recruitment Status
Recruiting (4)
Recruitment Country and State
NSW (4)
VIC (4)
QLD (3)
WA (3)
NZ (2)
SA (1)
Phase
Phase 1 (1)
Phase 2 (1)
Phase 4 (1)
Trial Type
Paed (4)
Cancer Therapy Class
CDK4
25%
CDK6
25%
mTOR
25%
mTORC1
25%
PD-1
25%
PD-1/PD-L1
25%
BRAF
25%
BRAF V600
25%
MEK
25%
RAF
25%
Facility
2031 - Randwick - Sydney Children's Hospital (3)
4101 - South Brisbane - Queensland Children's Hospital (3)
6009 - Perth - Perth Children's Hospital (3)
3053 - Parkville - The Royal Women's Hospital and Institute of Maternal and Child Health (2)
NZ.1023 - Grafton - Starship Children's Hospital (2)
3052 - Parkville - Royal Children's Hospital Melbourne (2)
2145 - Westmead - The Children's Hospital at Westmead (1)
5006 - North Adelaide - Women's and Children's Hospital-Adelaide Cancer Centre (1)
2010 - Darlinghurst - St Vincent's Hospital Sydney - The Kinghorn Cancer Centre (1)
Cancer Type
Cancer
Central nervous system cancer
Glioblastoma
Glioma
High-grade glioma
Malignant glioma
Neurological cancer
Solid tumour
Anaplastic astrocytoma
Diffuse intrinsic pontine glioma
H3K27M-mutant glioma
Diffuse hemispheric glioma
Anaplastic ganglioglioma
Anaplastic oligodendroglioma
Anaplastic pleomorphic xanthoastrocytoma
Astrocytoma
Benign glioma
Central neurocytoma
Desmoplastic infantile astrocytoma
Diffuse astrocytoma
Extra-ventricular Neurocytoma
Gangliocytoma
Ganglioglioma
Glioneuronal tumour
Liponeurocytoma
Low-grade glioma
Neuroblastic tumour
Neurofibromatosis
Oligodendroglioma
Papillary glioneuronal tumour
Peripheral nervous system tumour
Pilocytic astrocytoma
Pleomorphic xanthoastrocytoma
Rosette-forming glioneuronal tumour
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