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Annotated Registry of Trials in Cancer, Australia and New Zealand Ed.
- Results - target/BTK-PROTAC-degrader
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ARTICANZ provides informational content about cancer drug trials in Australia/NZ that is updated weekly but may not be completely accurate, and should not replace medical advice from qualified healthcare professionals. The platform is intended to be useful, providing information "as is" without warranties. Non-medical users must always consult healthcare providers for all clinical decisions.
Search results
target/BTK-PROTAC-degrader
4
trial(s) found.
NCT06973187
Haem
Phase 3
Not yet recruiting
A Phase 3, Open-Label, Randomized Study to Evaluate the Safety and Efficacy of BGB-16673 Compared to Pirtobrutinib in Patients With Relapsed/Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma (
2025-522860-34-00--BGB-16673-304
)
BTK PROTAC degrader
BTK inhibitor
Chronic lymphocytic leukaemia
Small Lymphocytic Lymphoma
QLD
4575 - Birtinya - Sunshine Coast University Hospital
NCT06846671
Haem
Phase 3
Recruiting
A Phase 3, Open-Label, Randomized Study of BGB-16673 Compared to Investigator's Choice (Idelalisib Plus Rituximab or Bendamustine Plus Rituximab or Venetoclax Plus Rituximab Retreatment) in Patients With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Previously Exposed to Both BTK and BCL2 Inhibitors (
CaDAnCe-302
)
BTK PROTAC degrader
Bcl2 inhibitor
PI3K delta inhibitor
alkylating agent
anti-CD20 monoclonal antibody
Chronic lymphocytic leukaemia
Small lymphocytic lymphoma
NSW
2139 - Concord - Concord Repatriation General Hospital
2250 - Gosford - Central Coast Cancer Centre, Gosford Hospital
2444 - Port Macquarie - Mid North Coast Cancer Institute-Port Macquarie Base Hospital
VIC
3004 - Melbourne, Southbank - Alfred Health
QLD
4350 - Toowoomba - ICON Cancer Centre Toowoomba
SA
5042 - Bedford Park - Southern Oncology Clinical Research Unit
WA
6005 - West Perth - Sir Charles Gairdner Hospital / Western Heamatology and Oncology Clinics
NZ
NZ.1023 - Grafton - Auckland City Hospital - Cancer & Blood Research
NCT06634589
Haem
Phase 1
Recruiting
A Phase 1b/2, Open-Label, Master Protocol Study of BTK-Degrader BGB-16673 in Combination With Other Agents in Patients With Relapsed or Refractory B-Cell Malignancies (
2024-516234-35-00--BGB-16673-104
)
BTK PROTAC degrader
B-cell lymphoma
NSW
2217 - Kogarah - St George Hospital
VIC
3000 - Melbourne - Peter MacCallum Cancer Centre
3004 - Melbourne, Southbank - Alfred Health
3168 - Clayton - Monash Medical Centre
QLD
4101 - South Brisbane - Mater Hospital Brisbane / ICON Cancer Centre
WA
6009 - Nedlands - Sir Charles Gairdner Hospital - WA Cancer Centre
NZ
NZ.1023 - Grafton - Auckland City Hospital - Cancer & Blood Research
NCT05006716
Haem
Phase 1
Recruiting
A Phase 1/2, Open-Label, Dose-Escalation and -Expansion Study of the Bruton Tyrosine Kinase Targeted Protein Degrader BGB-16673 in Patients With B-Cell Malignancies (
CaDAnCe-101
)
BTK PROTAC degrader
B-cell malignancy
Chronic lymphocytic leukaemia
Diffuse large B-cell lymphoma
Follicular lymphoma
Mantle cell lymphoma
Marginal zone lymphoma
Non-Hodgkin's lymphoma
Small Lymphocytic Lymphoma
Waldenström Macroglobulinemia
NSW
2139 - Concord - Concord Repatriation General Hospital
2298 - Waratah - Calvary Mater Newcastle Medical Oncology
VIC
3000 - Melbourne - Peter MacCallum Cancer Centre
3004 - Melbourne, Southbank - Alfred Health
3065 - Fitzroy - St Vincent's Hospital Melbourne
3084 - Heidelberg - Austin Hospital Olivia Newton-John Cancer Centre
3199 - Frankston - Peninsula Health Frankston Hospital
QLD
4102 - Woolloongabba - Princess Alexandra Hospital
WA
6005 - West Perth - Sir Charles Gairdner Hospital / Western Heamatology and Oncology Clinics
6009 - Nedlands - Sir Charles Gairdner Hospital - WA Cancer Centre
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Recruitment Status
Recruiting (3)
Not yet recruiting (1)
Recruitment Country and State
QLD (4)
NSW (3)
VIC (3)
WA (3)
NZ (2)
SA (1)
Phase
Phase 1 (2)
Phase 3 (2)
Trial Type
Haem (4)
Cancer Therapy Class
BTK
100%
Bcl2
50%
CD20
50%
PI3K delta
25%
Facility
3004 - Melbourne, Southbank - Alfred Health (3)
2139 - Concord - Concord Repatriation General Hospital (2)
6005 - West Perth - Sir Charles Gairdner Hospital / Western Heamatology and Oncology Clinics (2)
NZ.1023 - Grafton - Auckland City Hospital - Cancer & Blood Research (2)
3000 - Melbourne - Peter MacCallum Cancer Centre (2)
6009 - Nedlands - Sir Charles Gairdner Hospital - WA Cancer Centre (2)
4575 - Birtinya - Sunshine Coast University Hospital (1)
2250 - Gosford - Central Coast Cancer Centre, Gosford Hospital (1)
2444 - Port Macquarie - Mid North Coast Cancer Institute-Port Macquarie Base Hospital (1)
4350 - Toowoomba - ICON Cancer Centre Toowoomba (1)
5042 - Bedford Park - Southern Oncology Clinical Research Unit (1)
2217 - Kogarah - St George Hospital (1)
3168 - Clayton - Monash Medical Centre (1)
4101 - South Brisbane - Mater Hospital Brisbane / ICON Cancer Centre (1)
2298 - Waratah - Calvary Mater Newcastle Medical Oncology (1)
3065 - Fitzroy - St Vincent's Hospital Melbourne (1)
3084 - Heidelberg - Austin Hospital Olivia Newton-John Cancer Centre (1)
3199 - Frankston - Peninsula Health Frankston Hospital (1)
4102 - Woolloongabba - Princess Alexandra Hospital (1)
Cancer Type
B-cell lymphoma
B-cell malignancy
Cancer
Haematological malignancy
Lymphoma
Mature B-cell malignancy
Non-Hodgkin's lymphoma
Chronic lymphocytic leukaemia
Leukaemia
Lymphoid leukaemia
Small lymphocytic lymphoma
Diffuse large B-cell lymphoma
Follicular lymphoma
High-grade B-cell lymphoma
Mantle cell lymphoma
Marginal zone lymphoma
Waldenström Macroglobulinaemia
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