ARTICANZ - Beta (ver 0.91)
Annotated Registry of Trials in Cancer, Australia and New Zealand Ed.
- Results - target/EGFR-inhibitor-third-generation
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ARTICANZ provides informational content about cancer drug trials in Australia/NZ that is updated weekly but may not be completely accurate, and should not replace medical advice from qualified healthcare professionals. The platform is intended to be useful, providing information "as is" without warranties. Non-medical users must always consult healthcare providers for all clinical decisions.
Search results
target/EGFR-inhibitor-third-generation
13
trial(s) found.
NCT07699328
Advanced
Phase 1 / Phase 2
Recruiting
A Phase 1/2 Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of VRN110755 in Patients With Epidermal Growth Factor Receptor (EGFR) Mutant Non-Small Cell Lung Cancer (NSCLC) (
REACH-EGFR
)
EGFR inhibitor,fourth generation
+ EGFR inhibitor,third generation
EGFR-mutant non-small cell lung cancer
VIC
3168 - Clayton - Monash Medical Centre
SA
5042 - Bedford Park - Southern Oncology Clinical Research Unit
NCT07680790
Advanced
Phase 3
Not yet recruiting
A Phase III, Randomized, Open-label Study of Izalontamab Brengitecan (BMS-986507) in Combination With Osimertinib Versus Osimertinib Monotherapy or Osimertinib in Combination With Platinum-based Chemotherapy as First-Line Therapy in Patients With EGFR-Mutant Locally Advanced or Metastatic Non-small Cell Lung Cancer (
CA244-0020
)
EGFR inhibitor,third generation
bispecific EGFR/ERBB3 antibody
Non-small cell lung cancer
NSW
2050 - Camperdown - Chris O'Brien Lifehouse
2145 - Westmead - The Crown Princess Mary Cancer Centre - Westmead Hospital
VIC
3168 - Clayton - Monash Medical Centre
QLD
4120 - Greenslopes - Greenslopes Private Hospital
SA
5000 - Adelaide - Royal Adelaide Hospital - Adelaide Cancer Centre
WA
6150 - Murdoch - Fiona Stanley Hospital
NCT07185997
Advanced
Phase 3
Recruiting
A Global, Phase 3, Randomized, Multicenter, Open-Label Study to Evaluate the Efficacy and Safety of Firmonertinib Compared With Investigator's Choice of Osimertinib or Afatinib as First-Line Treatment in Participants Who Have Locally Advanced or Metastatic Non-Small-Cell Lung Cancer With Epidermal Growth Factor Receptor P-Loop and Alpha C-Helix Compressing (PACC) Uncommon Mutations (ALPACCA) (
FURMO-006
)
EGFR inhibitor,second generation
EGFR inhibitor,third generation
ERBB2 inhibitor,second generation
Non-small cell lung cancer
NSW
2050 - Camperdown - Chris O'Brien Lifehouse
2065 - St Leonards - GenesisCare North Shore Private Hospital
2148 - Blacktown - Blacktown Hospital, Blacktown Cancer and Haematology Centre
VIC
3084 - Heidelberg - Austin Hospital Olivia Newton-John Cancer Centre
NCT07155187
Advanced
Phase 2 / Phase 3
Recruiting
A Phase 2/3 Open Label Randomized Study of Telisotuzumab Adizutecan, Monotherapy or in Combination With Osimertinib, Compared to Standard of Care in Subjects With Locally Advanced or Metastatic EGFR-Mutated Non-Squamous Non-Small Cell Lung Cancer After Progression on a Third-Generation EGFR TKI - AndroMETa-Lung-713 (
M25-713
)
EGFR inhibitor,third generation
anti-cMET antibody-drug conjugate
Non-small cell lung cancer
NSW
2217 - Kogarah - St George Hospital
ACT
2605 - Garran - The Canberra Hospital
VIC
3021 - St Albans - Western Health - Sunshine Hospital
3065 - Fitzroy - St Vincent's Hospital Melbourne
QLD
4101 - South Brisbane - Mater Hospital Brisbane / ICON Cancer Centre
WA
6009 - Nedlands - One Clinical Research
TAS
7000 - Hobart - ICON Cancer Care Hobart
NCT07005102
Advanced
Phase 2 / Phase 3
Recruiting
A Phase 2/3 Randomized Study to Evaluate the Safety, Efficacy, and Optimal Dose of Telisotuzumab Adizutecan in Combination With Osimertinib as First-Line Treatment in Patients With Locally Advanced Unresectable or Metastatic EGFR-Mutated Non-Squamous Non-Small Cell Lung Cancer (
M25-287
)
EGFR inhibitor,third generation
anti-cMET antibody-drug conjugate
Non-small cell lung cancer
Non-squamous non-small-cell lung cancer
NSW
2170 - Liverpool - Liverpool Hospital
VIC
3084 - Heidelberg - Austin Hospital Olivia Newton-John Cancer Centre
SA
5011 - Woodville South - The Queen Elizabeth Hospital
WA
6150 - Murdoch - St John of God Murdoch Hospital
NCT06618287
Advanced
Phase 1 / Phase 2
Recruiting
A Phase 1/2a, Open-label, Dose-finding Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of BMS-986507 (BL-B01D1) Combinations in Adult Participants With Advanced Solid Tumors (
CA244-0001
)
bispecific EGFR/ERBB3 antibody
+ EGFR inhibitor,third generation
Breast cancer
Non-small cell lung cancer
NSW
2170 - Liverpool - Liverpool Hospital
VIC
3002 - East Melbourne - Epworth Freemasons
QLD
4102 - Woolloongabba - Princess Alexandra Hospital
WA
6008 - Subiaco - Bendat Family Comprehensive Cancer Centre - St John of God Subiaco Hospital
NCT06417814
Advanced
Phase 3
Recruiting
A Phase III, Open-label, Sponsor-blind, Randomized Study of Dato-DXd With or Without Osimertinib Versus Platinum-based Doublet Chemotherapy for Participants With EGFR-mutated Locally Advanced or Metastatic Non-small Cell Lung Cancer Whose Disease Has Progressed on Prior Osimertinib Treatment (
TROPION-Lung15
)
EGFR inhibitor,third generation
anti-Trop2 antibody-drug conjugate
Non-small cell lung cancer
NSW
2065 - St Leonards - Northern Sydney Cancer Centre, Royal North Shore Hospital
2145 - Westmead - The Crown Princess Mary Cancer Centre - Westmead Hospital
2170 - Liverpool - Liverpool Hospital
2217 - Kogarah - St George Hospital
2444 - Port Macquarie - Mid North Coast Cancer Institute-Port Macquarie Base Hospital
VIC
3065 - Fitzroy - St Vincent's Hospital Melbourne
3084 - Heidelberg - Austin Hospital Olivia Newton-John Cancer Centre
QLD
4102 - Woolloongabba - Princess Alexandra Hospital
SA
5011 - Woodville South - The Queen Elizabeth Hospital (WITHDRAWN)
WA
6009 - Nedlands - Sir Charles Gairdner Hospital - WA Cancer Centre
NCT06350097
Advanced
Phase 3
Recruiting
A Phase III, Open-label, Randomised Study of Osimertinib With or Without Datopotamab Deruxtecan (Dato-DXd), as First-line Treatment in Participants With Epidermal Growth Factor Receptor (EGFR) Mutation-positive, Locally Advanced or Metastatic Non-small Cell Lung Cancer (
TROPION-Lung14
)
EGFR inhibitor,third generation
anti-Trop2 antibody-drug conjugate
Non-small cell lung cancer
NSW
2050 - Camperdown - Chris O'Brien Lifehouse
2145 - Westmead - The Crown Princess Mary Cancer Centre - Westmead Hospital
2217 - Kogarah - St George Hospital
VIC
3168 - Clayton - Monash Medical Centre
QLD
4101 - South Brisbane - Mater Hospital Brisbane / ICON Cancer Centre
NCT05498428
Advanced
Phase 2
Recruiting
A Phase 2, Open-Label, Parallel Cohort Study of Subcutaneous Amivantamab in Multiple Regimens in Patients With Advanced or Metastatic Solid Tumors Including EGFR-mutated Non-Small Cell Lung Cancer (
PALOMA-2
)
bispecific cMET/EGFR antibody
+ EGFR inhibitor,third generation
Non-small cell lung cancer
NCT05142189
Advanced
Phase 1
Recruiting
LuCa-MERIT-1
: First-in-human, Open Label, Phase I Dose Confirmation Trial Evaluating the Safety, Tolerability and Preliminary Efficacy of BNT116 Alone and in Combinations in Patients With Advanced Non-small Cell Lung Cancer
vaccine therapy,MAGE-A3/CLDN6/KK-LC-1/PRAME/MAGE-A4/MAGE-C1-targeting
+ EGFR inhibitor,third generation
Non-small cell lung cancer
NSW
2031 - Randwick - Scientia Clinical Research Ltd
2065 - St Leonards - Northern Sydney Cancer Centre, Royal North Shore Hospital
VIC
3168 - Clayton - Monash Medical Centre
SA
5000 - Adelaide - Cancer Research SA
NCT04665206
Advanced
Phase 1 / Phase 2
Recruiting
Phase I/II, Multi-Center, Open-Label Study of VT3989, Alone or in Combination, in Patients With Locally Advanced or Metastatic Solid Tumors (
VT3989-001
)
TEAD palmitoylation inhibitor
+ EGFR inhibitor,third generation
Mesothelioma
Non-small cell lung cancer
Solid tumour
VIC
3000 - Melbourne - Peter MacCallum Cancer Centre
3168 - Clayton - Monash Medical Centre
WA
6009 - Nedlands - Linear Clinical Research
ACTRN12626000325303
Advanced
Phase 1
Recruiting
A Phase 1 Dose Escalation and Expansion Study to Investigate the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of Intravenous RC220 in Combination with Osimertinib in Patients with EGFR-mutant Non-Small Cell Lung Cancer (
HARNESS-1
)
EGFR inhibitor,third generation
anthracycline
antimetabolite
Non-small cell lung cancer
VIC
3168 - Clayton - Monash Medical Centre
ACTRN12623000552684
Curative
Phase 2
Recruiting
OCEANiC
: A Phase II, Open-label, Multi-centre Clinical Trial on effect of Osimertinib, With or Without Adjuvant Chemotherapy, Guided by High-risk Tumour Next Generation Sequencing (NGS) Co-mutation Status and circulating tumour DNA (ctDNA) Detection on disease-free survival in Patients With Stage IIA-IIIA epidermal growth factor receptor (EGFR)-Mutant Non Small Cell Lung Cancer Following Complete Surgical Resection
EGFR inhibitor,third generation
EGFR-mutant non-small cell lung cancer
NSW
2050 - Camperdown - Chris O'Brien Lifehouse
2065 - St Leonards - Northern Sydney Cancer Centre, Royal North Shore Hospital
2145 - Westmead - The Crown Princess Mary Cancer Centre - Westmead Hospital
2170 - Liverpool - Liverpool Hospital
VIC
3000 - Melbourne - Peter MacCallum Cancer Centre
3066 - Epping - Northern Hospital
3084 - Heidelberg - Austin Hospital Olivia Newton-John Cancer Centre
3168 - Clayton - Monash Medical Centre
QLD
4032 - Chermside - The Prince Charles Hospital
SA
5042 - Bedford Park - Flinders Medical Centre
WA
6150 - Murdoch - Fiona Stanley Hospital
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Recruitment Status
Recruiting (12)
Not yet recruiting (1)
Recruitment Country and State
VIC (12)
NSW (9)
WA (7)
QLD (6)
SA (5)
ACT (1)
TAS (1)
Phase
Phase 1 (2)
Phase 1 / Phase 2 (3)
Phase 2 (2)
Phase 2 / Phase 3 (2)
Phase 3 (4)
Trial Type
Advanced (12)
Curative (1)
Cancer Therapy Class
EGFR
100%
MET
23%
PD-1
23%
PD-1/PD-L1
23%
ERBB3
15%
Trop2
15%
ERBB2
8%
PD-L1
8%
VEGFA
8%
CLDN6
8%
MAGE-A3
8%
MAGE-A4
8%
MAGE-C1
8%
PRAME
8%
CTLA4
8%
YAP-TEAD
8%
Facility
3168 - Clayton - Monash Medical Centre (7)
2050 - Camperdown - Chris O'Brien Lifehouse (4)
2145 - Westmead - The Crown Princess Mary Cancer Centre - Westmead Hospital (4)
3084 - Heidelberg - Austin Hospital Olivia Newton-John Cancer Centre (4)
2170 - Liverpool - Liverpool Hospital (4)
2217 - Kogarah - St George Hospital (3)
2065 - St Leonards - Northern Sydney Cancer Centre, Royal North Shore Hospital (3)
6150 - Murdoch - Fiona Stanley Hospital (2)
3065 - Fitzroy - St Vincent's Hospital Melbourne (2)
4101 - South Brisbane - Mater Hospital Brisbane / ICON Cancer Centre (2)
5011 - Woodville South - The Queen Elizabeth Hospital (2)
4102 - Woolloongabba - Princess Alexandra Hospital (2)
3000 - Melbourne - Peter MacCallum Cancer Centre (2)
5042 - Bedford Park - Southern Oncology Clinical Research Unit (1)
4120 - Greenslopes - Greenslopes Private Hospital (1)
5000 - Adelaide - Royal Adelaide Hospital - Adelaide Cancer Centre (1)
2065 - St Leonards - GenesisCare North Shore Private Hospital (1)
2148 - Blacktown - Blacktown Hospital, Blacktown Cancer and Haematology Centre (1)
2605 - Garran - The Canberra Hospital (1)
3021 - St Albans - Western Health - Sunshine Hospital (1)
6009 - Nedlands - One Clinical Research (1)
7000 - Hobart - ICON Cancer Care Hobart (1)
6150 - Murdoch - St John of God Murdoch Hospital (1)
3002 - East Melbourne - Epworth Freemasons (1)
6008 - Subiaco - Bendat Family Comprehensive Cancer Centre - St John of God Subiaco Hospital (1)
2444 - Port Macquarie - Mid North Coast Cancer Institute-Port Macquarie Base Hospital (1)
6009 - Nedlands - Sir Charles Gairdner Hospital - WA Cancer Centre (1)
2031 - Randwick - Scientia Clinical Research Ltd (1)
5000 - Adelaide - Cancer Research SA (1)
6009 - Nedlands - Linear Clinical Research (1)
3066 - Epping - Northern Hospital (1)
4032 - Chermside - The Prince Charles Hospital (1)
5042 - Bedford Park - Flinders Medical Centre (1)
Cancer Type
Cancer
Lung cancer
Non-small cell lung cancer
Respiratory tract cancer
Solid tumour
Thoracic cancer
EGFR-mutant non-small cell lung cancer
Non-squamous non-small-cell lung cancer
Breast cancer
Mesothelioma
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