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Annotated Registry of Trials in Cancer, Australia and New Zealand Ed.
- Results - target/EZH2-inhibitor
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ARTICANZ provides informational content about cancer drug trials in Australia/NZ that is updated weekly but may not be completely accurate, and should not replace medical advice from qualified healthcare professionals. The platform is intended to be useful, providing information "as is" without warranties. Non-medical users must always consult healthcare providers for all clinical decisions.
Search results
target/EZH2-inhibitor
4
trial(s) found.
NCT07028853
Advanced
Phase 3
Recruiting
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of Mevrometostat (PF-06821497) With Enzalutamide in Metastatic Castration-Sensitive Prostate Cancer (MEVPRO-3) (
C2321008
)
EZH2 inhibitor
antiandrogen,nonsteroidal,second generation
placebo
Castrate-sensitive prostate cancer
Prostate cancer
NSW
2076 - Wahroonga - Sydney Adventist Hospital
2800 - Orange - Orange Hospital-Cancer Centre Clinical Trials Unit
QLD
4032 - Chermside - Icon Cancer Care Chermside
4101 - South Brisbane - Mater Hospital Brisbane / ICON Cancer Centre
SA
5037 - Kurralta Park - Icon Cancer Centre Adelaide
WA
6009 - Nedlands - Sir Charles Gairdner Hospital - WA Cancer Centre
NZ
NZ.3112 - Tauranga - Tauranga Hospital, Bay of Plenty Clinical Trials Unit
NZ.3210 - Hamilton - Waikato Hospital
NZ.4442 - Roslyn - Palmerston North Hospital Cancer Centre - Palmerston North Hospital
NCT06629779
Advanced
Phase 3
Recruiting
A PHASE 3, RANDOMIZED, DOUBLE BLIND, PLACEBO CONTROLLED STUDY OF PF-06821497 (MEVROMETOSTAT) WITH ENZALUTAMIDE IN METASTATIC CASTRATION RESISTANT PROSTATE CANCER (MEVPRO-2) (
C2321003
)
EZH2 inhibitor
antiandrogen,nonsteroidal,second generation
placebo
Castrate-resistant prostate cancer
NZ
NZ.1023 - Grafton - Auckland City Hospital - Cancer & Blood Research
NZ.3112 - Tauranga - Tauranga Hospital, Bay of Plenty Clinical Trials Unit
NZ.3210 - Hamilton - Waikato Hospital
NZ.8011 - Christchurch - Canterbury District Health Board - Christchurch Hospital Cancer Centre
NCT06551324
Advanced
Phase 3
Recruiting
A PHASE 3, RANDOMIZED, OPEN-LABEL STUDY OF PF-06821497 (MEVROMETOSTAT) IN COMBINATION WITH ENZALUTAMIDE COMPARED WITH ENZALUTAMIDE OR DOCETAXEL IN PARTICIPANTS WITH METASTATIC CASTRATION RESISTANT PROSTATE CANCER PREVIOUSLY TREATED WITH ABIRATERONE ACETATE (
MEVPRO-1
)
CYP17A1 inhibitor
EZH2 inhibitor
antiandrogen,nonsteroidal,second generation
taxane
Castrate-resistant prostate cancer
VIC
3000 - Melbourne - Peter MacCallum Cancer Centre
3168 - Clayton - Monash Medical Centre
QLD
4066 - Auchenflower - Icon Cancer Centre at Wesley Hospital
NCT05598151
Advanced
Phase 1
Recruiting
A Phase I, Open-Label, Multicenter, Dose Escalation and Expansion Study of HM97662 as a Single Agent in Patients With Advanced or Metastatic Solid Tumors (
HM-EZHI-101
)
EZH1/2 inhibitor
+ EZH2 inhibitor
Solid tumour
VIC
3168 - Clayton - Monash Medical Centre
3199 - Frankston - Peninsula Health Frankston Hospital
3350 - Ballarat - Grampians Health Service's Ballarat Base Hospital
SA
5000 - Adelaide - Royal Adelaide Hospital - Adelaide Cancer Centre
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Recruitment Status
Recruiting (4)
Recruitment Country and State
NZ (2)
QLD (2)
SA (2)
VIC (2)
NSW (1)
WA (1)
Phase
Phase 1 (1)
Phase 3 (3)
Trial Type
Advanced (4)
Cancer Therapy Class
EZH2
100%
AR
75%
androgen axis
75%
CYP17A1
25%
EZH1
25%
Facility
NZ.3112 - Tauranga - Tauranga Hospital, Bay of Plenty Clinical Trials Unit (2)
NZ.3210 - Hamilton - Waikato Hospital (2)
3168 - Clayton - Monash Medical Centre (2)
2076 - Wahroonga - Sydney Adventist Hospital (1)
2800 - Orange - Orange Hospital-Cancer Centre Clinical Trials Unit (1)
4032 - Chermside - Icon Cancer Care Chermside (1)
4101 - South Brisbane - Mater Hospital Brisbane / ICON Cancer Centre (1)
5037 - Kurralta Park - Icon Cancer Centre Adelaide (1)
6009 - Nedlands - Sir Charles Gairdner Hospital - WA Cancer Centre (1)
NZ.4442 - Roslyn - Palmerston North Hospital Cancer Centre - Palmerston North Hospital (1)
NZ.1023 - Grafton - Auckland City Hospital - Cancer & Blood Research (1)
NZ.8011 - Christchurch - Canterbury District Health Board - Christchurch Hospital Cancer Centre (1)
3000 - Melbourne - Peter MacCallum Cancer Centre (1)
4066 - Auchenflower - Icon Cancer Centre at Wesley Hospital (1)
3199 - Frankston - Peninsula Health Frankston Hospital (1)
3350 - Ballarat - Grampians Health Service's Ballarat Base Hospital (1)
5000 - Adelaide - Royal Adelaide Hospital - Adelaide Cancer Centre (1)
Cancer Type
Cancer
Solid tumour
Male genital cancers
Prostate adenocarcinoma
Prostate cancer
Urogenital cancer
Castrate-resistant prostate cancer
Castrate-sensitive prostate cancer
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