ARTICANZ - Beta (ver 0.9)
Annotated Registry of Trials in Cancer, Australia and New Zealand Ed.
- Results - target/FAK
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ARTICANZ provides informational content about cancer drug trials in Australia/NZ that is updated weekly but may not be completely accurate, and should not replace medical advice from qualified healthcare professionals. The platform is intended to be useful, providing information "as is" without warranties. Non-medical users must always consult healthcare providers for all clinical decisions.
Search results
target/FAK
4
trial(s) found.
NCT06072781
Advanced
Phase 3
Recruiting
A Phase 3, Randomized, Open-Label Study of Combination Therapy With Avutometinib Plus Defactinib Versus Investigator's Choice of Treatment in Patients With Recurrent Low-Grade Serous Ovarian Cancer (LGSOC) (RAMP 301) (
RAMP-301
)
FAK inhibitor
RAF/MEK clamp
Low-grade serous ovarian cancer
NSW
2031 - Randwick - Prince of Wales Hospital
VIC
3000 - Melbourne - Peter MacCallum Cancer Centre
QLD
4066 - Auchenflower - Icon Cancer Centre at Wesley Hospital
SA
5000 - Adelaide - Royal Adelaide Hospital - Adelaide Cancer Centre
WA
6009 - Nedlands - Sir Charles Gairdner Hospital - WA Cancer Centre
NZ
NZ.1023 - Grafton - Auckland City Hospital - Cancer & Blood Research
NCT05636514
Haem
Phase 1
Recruiting
A Phase I Study of Oral Decitabine and Cedazuridine (ASTX727) In Combination With Defactinib (VS-6063) as Therapy of Myelodysplastic Syndromes and Low-blast Acute Myeloid Leukaemia (
CELESTIAL-MDS
)
DNA methyltransferase inhibitor
FAK inhibitor
cytidine deaminase inhibitor
Acute myeloid leukaemia
Chronic myelomonocytic leukaemia
Myelodysplastic syndrome
NSW
2031 - Randwick - Prince of Wales Hospital
2050 - Camperdown - Chris O'Brien Lifehouse
2139 - Concord - Concord Repatriation General Hospital
2145 - Westmead - The Crown Princess Mary Cancer Centre - Westmead Hospital
2747 - Kingswood - Nepean Hospital - Nepean Cancer Care Centre
ACTRN12623000174684
Advanced
Phase 1
Recruiting
A Phase Ib/II Study of APG-2449 in Combination with Doxorubicin Hydrochloride Liposome in Patients with Ovarian Cancer (
APG2449OG101
)
ALK inhibitor,third generation
FAK/ALK/ROS1 inhibitor
FAK inhibitor
anthracycline
Ovarian cancer
NSW
2050 - Camperdown - Chris O'Brien Lifehouse
2148 - Blacktown - Blacktown Hospital, Blacktown Cancer and Haematology Centre
QLD
4101 - South Brisbane - Mater Hospital Brisbane / ICON Cancer Centre
NCT05355298
Advanced
Phase 1 / Phase 2
Active not recruiting
A Phase 1b/2a, Multicentre, Open Label Study of the Pharmacokinetics, Safety and Efficacy of AMP945 in Combination with Nab-paclitaxel and Gemcitabine in Pancreatic Cancer Patients (
AMP945-PC-201
)
FAK inhibitor
antimetabolite
taxane
Pancreatic adenocarcinoma
Pancreatic cancer
NSW
2065 - St Leonards - GenesisCare North Shore Private Hospital
2145 - Westmead - The Crown Princess Mary Cancer Centre - Westmead Hospital
2298 - Waratah - Calvary Mater Newcastle Medical Oncology
VIC
3021 - St Albans - Western Health - Sunshine Hospital
3121 - Richmond - Epworth Freemasons Hospital
3128 - Box Hill - Box Hill Hospital - Eastern Health
3168 - Clayton - Monash Medical Centre
QLD
4120 - Greenslopes - Greenslopes Private Hospital- Gallipoli Medical Research Foundation
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Recruitment Status
Recruiting (3)
Active not recruiting (1)
Recruitment Country and State
NSW (4)
QLD (3)
VIC (2)
NZ (1)
SA (1)
WA (1)
Phase
Phase 1 (2)
Phase 1 / Phase 2 (1)
Phase 3 (1)
Trial Type
Advanced (3)
Haem (1)
Cancer Therapy Class
FAK
100%
BRAF
25%
CRAF
25%
MEK
25%
RAF
25%
pan-RAF
25%
oestrogen axis
25%
DNA methyltransferase
25%
cytidine deaminase
25%
ALK
25%
ROS1
25%
Facility
2031 - Randwick - Prince of Wales Hospital (2)
2050 - Camperdown - Chris O'Brien Lifehouse (2)
2145 - Westmead - The Crown Princess Mary Cancer Centre - Westmead Hospital (2)
3000 - Melbourne - Peter MacCallum Cancer Centre (1)
4066 - Auchenflower - Icon Cancer Centre at Wesley Hospital (1)
5000 - Adelaide - Royal Adelaide Hospital - Adelaide Cancer Centre (1)
6009 - Nedlands - Sir Charles Gairdner Hospital - WA Cancer Centre (1)
NZ.1023 - Grafton - Auckland City Hospital - Cancer & Blood Research (1)
2139 - Concord - Concord Repatriation General Hospital (1)
2747 - Kingswood - Nepean Hospital - Nepean Cancer Care Centre (1)
2148 - Blacktown - Blacktown Hospital, Blacktown Cancer and Haematology Centre (1)
4101 - South Brisbane - Mater Hospital Brisbane / ICON Cancer Centre (1)
2065 - St Leonards - GenesisCare North Shore Private Hospital (1)
2298 - Waratah - Calvary Mater Newcastle Medical Oncology (1)
3021 - St Albans - Western Health - Sunshine Hospital (1)
3121 - Richmond - Epworth Freemasons Hospital (1)
3128 - Box Hill - Box Hill Hospital - Eastern Health (1)
3168 - Clayton - Monash Medical Centre (1)
4120 - Greenslopes - Greenslopes Private Hospital- Gallipoli Medical Research Foundation (1)
Cancer Type
Cancer
Solid tumour
Gynaecological cancer
Ovarian cancer
Epithelial Ovarian Cancer
Low-grade serous ovarian cancer
Ovarian adenocarcinoma
Ovarian serous carcinoma
Acute myeloid leukaemia
Chronic myelomonocytic leukaemia
Haematological malignancy
Leukaemia
Myelodysplastic syndrome
Myelodysplastic/Myeloproliferative disease
Myeloid leukaemia
Myeloproliferative neoplasm
Exocrine pancreatic cancer
Gastrointestinal cancer
Pancreatic adenocarcinoma
Pancreatic cancer
Pancreatobiliary cancer
Upper gastrointestinal cancer
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