ARTICANZ - Beta (ver 0.91)
Annotated Registry of Trials in Cancer, Australia and New Zealand Ed.
- Results - target/IL-2
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ARTICANZ provides informational content about cancer drug trials in Australia/NZ that is updated weekly but may not be completely accurate, and should not replace medical advice from qualified healthcare professionals. The platform is intended to be useful, providing information "as is" without warranties. Non-medical users must always consult healthcare providers for all clinical decisions.
Search results
target/IL-2
9
trial(s) found.
NCT07681596
Haem
Phase 1 / Phase 2
Recruiting
A Modular, Phase I/II, Open-label, Multicentre Study to Evaluate the Safety, Tolerability, Cellular Kinetics, and Efficacy of AZD4045, an Allogeneic Chimeric Antigen Receptor-T Cell (CAR-T) Therapy Targeting B Cell Maturation Antigen (BCMA) in Participants With Relapsed or Refractory Multiple Myeloma (
D7540C00001
)
allogeneic CAR-T-cell therapy,BCMA-targeting
+ IL-2 variant
Multiple myeloma
NSW
2050 - Camperdown - Chris O'Brien Lifehouse
VIC
3002 - East Melbourne - Epworth Freemasons
NCT07651618
Advanced
Phase 2
Not yet recruiting
PERTIL-01
: A Phase II Trial of Tumour Infiltrating Lymphocyte Adoptive Cell Therapy in Patients With Immune Checkpoint Inhibitor Resistant Unresectable or Metastatic Melanoma
Aldesleukin
Cyclophosphamide
Fludarabine
IL-2 variant
alkylating agent
antimetabolite
cancer therapy
cancer therapy,IL-2-targeting
cytokine therapy
cytokine therapy,IL-2-targeting
cytotoxic chemotherapy
immuno-oncology therapy,IL-2-targeting
+ IL-2 variant
Melanoma
Skin cancer
WA
6000 - Perth - Royal Perth Hospital
NCT07063875
Advanced
Phase 1 / Phase 2
Recruiting
Supplementing With IL-2 to Verifiably eRadicate Radiological Progression (
SILVER
)
Aldesleukin
IL-2 variant
Tebentafusp
bispecfic T-cell engager,gp100-targeting
cancer therapy
cancer therapy,IL-2-targeting
cancer therapy,gp100-targeting
cytokine therapy
cytokine therapy,IL-2-targeting
immuno-oncology therapy,IL-2-targeting
+ IL-2 variant
Uveal melanoma
NSW
2010 - Darlinghurst - St Vincent's Hospital Sydney - The Kinghorn Cancer Centre
VIC
3004 - Melbourne, Southbank - Alfred Health
NCT06940739
Advanced
Phase 1 / Phase 2
Recruiting
A Phase 1/2, Open-label Study of a Modified Interleukin-2 Fusion Protein (IOV-3001) in Participants With Previously Treated, Unresectable or Metastatic Melanoma Who Will Receive Lifileucel (
IOV-IL2-101
)
IL-2 fusion protein
autologous tumor-infiltrating lymphocytes therapy
Melanoma
NOT Uveal melanoma
Uveal melanoma
QLD
4120 - Greenslopes - Greenslopes Private Hospital
WA
6009 - Nedlands - Hollywood Private Hospital
NCT05267626
Advanced
Phase 1 / Phase 2
Recruiting
A Phase 1/2, First-in-Human, Open Label, Dose Escalation and Expansion Study of AU-007, A Monoclonal Antibody That Binds to IL-2 and Inhibits IL-2Rα Binding, in Patients With Unresectable Locally Advanced or Metastatic Cancer (
CP-AU-007-01
)
anti-IL-2 monoclonal antibody
Cancer
Cutaneous melanoma
Non-small cell lung cancer
Solid tumour
NSW
2228 - Miranda - Southside Cancer Care Centre
VIC
3004 - Melbourne, Southbank - Alfred Health
3021 - St Albans - Western Health - Sunshine Hospital
3084 - Heidelberg - Austin Hospital Olivia Newton-John Cancer Centre
3168 - Clayton - Monash Medical Centre
3199 - Frankston - Peninsula Health Frankston Hospital
SA
5042 - Bedford Park - Southern Oncology Clinical Research Unit
NCT05086692
Advanced
Phase 1 / Phase 2
Recruiting
A Phase 1/2 Open Label, Dose Escalation and Expansion Study of MDNA11, IL-2 Superkine, Administered Alone or in Combination With Immune Checkpoint Inhibitor in Patients With Advanced Solid Tumors (
ABILITY-1
)
IL-2 superkine
Acral lentiginous melanoma
Bladder cancer
Cancer
Cervical cancer
Clear cell renal cell carcinoma
Colorectal cancer
Cutaneous basal cell carcinoma
Cutaneous melanoma
Cutaneous squamous cell carcinoma
Endometrial cancer
Endometrial carcinoma
Epithelial Ovarian Cancer
Fallopian tube cancer
Gastric cancer
Gastroesophageal junction adenocarcinoma
Head and neck squamous cell carcinoma
Melanoma
Merkel cell carcinoma
Mucosal melanoma
Non-melanoma skin cancer
Non-squamous non-small-cell lung cancer
Oesophageal cancer
Ovarian cancer
Pancreatic adenocarcinoma
Pleural mesothelioma
Primary peritoneal serous carcinoma
Skin cancer
Solid tumour
Squamous non-small-cell lung cancer
Triple-negative breast cancer
dMMR solid cancer
NSW
2031 - Randwick - Scientia Clinical Research Ltd
2109 - North Ryde - Macquarie University Hospital
QLD
4120 - Greenslopes - Greenslopes Private Hospital
4556 - Buderim - Sunshine Coast Haematology and Oncology Clinic
NCT04643002
Haem
Phase 1 / Phase 2
Recruiting
Phase 1-2 UMBRELLA Trial Evaluating Isatuximab With or Without Dexamethasone in Combination With Novel Agents Compared to Isatuximab With Pomalidomide and Dexamethasone in Relapsed or Refractory Multiple Myeloma (RRMM) - Master Protocol (
ACT16482
)
anti-CD38 monoclonal antibody
glucocorticoid
immunomodulatory imide drug
+ IL-2 variant
Multiple myeloma
NSW
2500 - Wollongong - Wollongong Hospital
VIC
3065 - Fitzroy - St Vincent's Hospital Melbourne
3121 - Richmond - Epworth Freemasons Hospital
ACTRN12626000394347
Advanced
Phase 2
Not yet recruiting
A Phase II Trial of Tumour Infiltrating Lymphocyte Adoptive Cell Therapy in Patients with Immune Checkpoint Inhibitor Resistant Unresectable or Metastatic Melanoma (
PERTIL-01
)
Aldesleukin
IL-2 variant
cancer therapy
cancer therapy,IL-2-targeting
cytokine therapy
cytokine therapy,IL-2-targeting
immuno-oncology therapy,IL-2-targeting
+ IL-2 variant
Melanoma
Skin cancer
ACTRN12623001217695
Advanced
Phase 1
Not yet recruiting
An Open-Label Dose-Escalation Phase Ia Clinical Trial to Evaluate the Safety, Tolerability and Preliminary Efficacy of IMD-101 Injectable in Participants with Advanced Malignant Solid Tumours.
IL2 conjugate
Solid tumour
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Recruitment Status
Recruiting (6)
Not yet recruiting (3)
Recruitment Country and State
NSW (5)
VIC (4)
WA (2)
QLD (2)
SA (1)
Phase
Phase 1 (1)
Phase 1 / Phase 2 (6)
Phase 2 (2)
Trial Type
Advanced (7)
Haem (2)
Cancer Therapy Class
IL-2
100%
CD38
22%
PD-1
22%
PD-1/PD-L1
22%
BCMA
11%
gp100
11%
PD-L1
11%
CD47
11%
ROCK2
11%
TGF-beta
11%
cereblon
11%
Facility
3004 - Melbourne, Southbank - Alfred Health (2)
4120 - Greenslopes - Greenslopes Private Hospital (2)
2050 - Camperdown - Chris O'Brien Lifehouse (1)
3002 - East Melbourne - Epworth Freemasons (1)
6000 - Perth - Royal Perth Hospital (1)
2010 - Darlinghurst - St Vincent's Hospital Sydney - The Kinghorn Cancer Centre (1)
6009 - Nedlands - Hollywood Private Hospital (1)
2228 - Miranda - Southside Cancer Care Centre (1)
3021 - St Albans - Western Health - Sunshine Hospital (1)
3084 - Heidelberg - Austin Hospital Olivia Newton-John Cancer Centre (1)
3168 - Clayton - Monash Medical Centre (1)
3199 - Frankston - Peninsula Health Frankston Hospital (1)
5042 - Bedford Park - Southern Oncology Clinical Research Unit (1)
2031 - Randwick - Scientia Clinical Research Ltd (1)
2109 - North Ryde - Macquarie University Hospital (1)
4556 - Buderim - Sunshine Coast Haematology and Oncology Clinic (1)
2500 - Wollongong - Wollongong Hospital (1)
3065 - Fitzroy - St Vincent's Hospital Melbourne (1)
3121 - Richmond - Epworth Freemasons Hospital (1)
Cancer Type
Cancer
Solid tumour
Melanoma
Skin cancer
Haematological malignancy
Multiple myeloma
Plasma cell disorder
Uveal melanoma
Cutaneous melanoma
Lung cancer
Non-small cell lung cancer
Respiratory tract cancer
Thoracic cancer
Acral lentiginous melanoma
Biomarker-defined solid tumour
Bladder cancer
Breast adenocarcinoma
Breast cancer
Cervical cancer
Clear cell renal cell carcinoma
Colorectal cancer
Cutaneous basal cell carcinoma
Cutaneous squamous cell carcinoma
Endometrial cancer
Endometrial carcinoma
Epithelial Ovarian Cancer
Exocrine pancreatic cancer
Fallopian tube cancer
Gastric cancer
Gastric carcinoma
Gastroesophageal cancer
Gastroesophageal junction adenocarcinoma
Gastrointestinal cancer
Gynaecological cancer
HPV-related cancer
HPV16-positive cancer
Head and neck cancer
Head and neck squamous cell carcinoma
High-grade serous carcinoma of the ovary, fallopian tube, and peritoneum
Kidney cancer
Lower gastrointestinal cancer
MSI-H/dMMR solid tumour
Merkel cell carcinoma
Mesothelioma
Mucosal melanoma
Non-melanoma skin cancer
Non-squamous non-small-cell lung cancer
Oesophageal cancer
Ovarian cancer
Pancreatic adenocarcinoma
Pancreatic cancer
Pancreatobiliary cancer
Peritoneal cancer
Pleural mesothelioma
Primary peritoneal serous carcinoma
Squamous non-small-cell lung cancer
Triple-negative breast cancer
Upper gastrointestinal cancer
Urogenital cancer
Viral-related cancer
dMMR solid cancer
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