ARTICANZ - Beta (ver 0.91)
Annotated Registry of Trials in Cancer, Australia and New Zealand Ed.
- Results - target/MEK
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ARTICANZ provides informational content about cancer drug trials in Australia/NZ that is updated weekly but may not be completely accurate, and should not replace medical advice from qualified healthcare professionals. The platform is intended to be useful, providing information "as is" without warranties. Non-medical users must always consult healthcare providers for all clinical decisions.
Search results
target/MEK
9
trial(s) found.
NCT06804824
Advanced
Phase 1
Recruiting
A Phase 1/1b, Open-Label, Multicenter, First-in-Human Dose Escalation and Dose Expansion Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Anti-Tumor Activity of VVD-159642, a RAS-PI3Kα Inhibitor, as a Single Agent and in Combination in Participants With Advanced Solid Tumors (
VVD-159642-01
)
RAS-PI3Kalpha inhibitor
+ MEK inhibitor
NOT Central nervous system cancer
Solid tumour
SA
5000 - Adelaide - Royal Adelaide Hospital - Adelaide Cancer Centre
WA
6009 - Nedlands - Linear Clinical Research
NCT06326411
Advanced
Phase 1
Recruiting
A Phase I, Open Label Single-arm Two-part Study to Investigate Safety, Pharmacokinetics, and Preliminary Efficacy of Pan-RAF/MEK Glue
NST-628
Oral Tablets in Subject With Solid Tumors Harboring Genetic Alterations in the MAPK Pathway and With Other Solid Tumors
pan-RAF/MEK glue
Glioma
Melanoma
NOT Melanoma
Non-small cell lung cancer
Solid tumour
NSW
2010 - Darlinghurst - St Vincent's Hospital Sydney - The Kinghorn Cancer Centre
2031 - Randwick - Scientia Clinical Research Ltd
VIC
3144 - Malvern - Cabrini Health, Cabrini Cancer Care Centre
QLD
4120 - Greenslopes - Greenslopes Private Hospital
SA
5042 - Bedford Park - Southern Oncology Clinical Research Unit
NCT06072781
Advanced
Phase 3
Recruiting
A Phase 3, Randomized, Open-Label Study of Combination Therapy With Avutometinib Plus Defactinib Versus Investigator's Choice of Treatment in Patients With Recurrent Low-Grade Serous Ovarian Cancer (LGSOC) (RAMP 301) (
RAMP-301
)
RAF/MEK clamp
Low-grade serous ovarian cancer
NSW
2031 - Randwick - Prince of Wales Hospital
VIC
3000 - Melbourne - Peter MacCallum Cancer Centre
QLD
4066 - Auchenflower - Icon Cancer Centre at Wesley Hospital
SA
5000 - Adelaide - Royal Adelaide Hospital - Adelaide Cancer Centre
WA
6009 - Nedlands - Sir Charles Gairdner Hospital - WA Cancer Centre
NZ
NZ.1023 - Grafton - Auckland City Hospital - Cancer & Blood Research
NCT05538130
Advanced
Phase 1
Recruiting
A PHASE 1A/B OPEN-LABEL MASTER STUDY OF PF-07799544 AS A SINGLE-AGENT AND IN COMBINATION WITH OTHER TARGETED AGENTS IN PARTICIPANTS WITH BRAF-MUTANT MELANOMA AND OTHER SOLID TUMORS (
C4901001
)
MEK inhibitor
Cancer
Central nervous system cancer
Differentiated thyroid carcinoma
Glioma
High-grade glioma
Low-grade glioma
Melanoma
Non-small cell lung cancer
Solid tumour
Thyroid cancer
VIC
3000 - Melbourne - Peter MacCallum Cancer Centre
3004 - Melbourne, Southbank - Alfred Health
NCT05203172
Advanced
Phase 4
Recruiting
ENCORAFENIB/BINIMETINIB MASTER PROTOCOL: AN OPEN-LABEL CONTINUATION STUDY FOR PARTICIPANTS CONTINUING FROM ENCORAFENIB/BINIMETINIB CLINICAL STUDIES (
C4221026
)
MEK inhibitor
Solid tumour
VIC
3000 - Melbourne - Peter MacCallum Cancer Centre
NCT03975829
Paed
Phase 4
Recruiting
An Open Label, Multi-center Roll-over Study to Assess Long-term Effect in Pediatric Patients Treated With Tafinlar (Dabrafenib) and/or Mekinist (Trametinib) (
CDRB436G2401
)
BRAF V600 inhibitor
+ MEK inhibitor
Anaplastic astrocytoma
Anaplastic ganglioglioma
Anaplastic oligodendroglioma
Anaplastic pleomorphic xanthoastrocytoma
Astrocytoma
Central neurocytoma
Desmoplastic infantile astrocytoma
Diffuse astrocytoma
Extra-ventricular Neurocytoma
Gangliocytoma
Ganglioglioma
Glioblastoma
Glioma
Liponeurocytoma
Neurofibromatosis
Oligodendroglioma
Papillary glioneuronal tumour
Pilocytic astrocytoma
Pleomorphic xanthoastrocytoma
Rosette-forming glioneuronal tumour
NSW
2010 - Darlinghurst - St Vincent's Hospital Sydney - The Kinghorn Cancer Centre
VIC
3052 - Parkville - Royal Children's Hospital Melbourne
NCT03947385
Advanced
Phase 1 / Phase 2
Recruiting
A Phase 1/2 Study of IDE196 in Patients With Solid Tumors Harboring GNAQ/11 Mutations or PRKC Fusions (
IDE196-001
)
PKC inhibitor
+ MEK inhibitor
Colorectal cancer
Cutaneous melanoma
Solid tumour
Uveal melanoma
NSW
2145 - Westmead - The Crown Princess Mary Cancer Centre - Westmead Hospital
QLD
4102 - Woolloongabba - Princess Alexandra Hospital
NCT05182931
Advanced
Phase 2
Unknown
A Prospective, Multi-Centre Trial of TKI Redifferentiation Therapy in Patients With RAIR Thyroid Cancer (
I-FIRST
Study)
BRAF V600 inhibitor
BRAF inhibitor
Dabrafenib
MEK inhibitor
RAF inhibitor
Trametinib
cancer therapy
cancer therapy,BRAF-targeting
cancer therapy,BRAF V600-targeting
cancer therapy,MEK-targeting
cancer therapy,RAF-targeting
+ MEK inhibitor
NOT Anaplastic thyroid cancer
Thyroid cancer
NSW
2065 - St Leonards - Northern Sydney Cancer Centre, Royal North Shore Hospital
VIC
3000 - Melbourne - Peter MacCallum Cancer Centre
3084 - Heidelberg - Austin Hospital Olivia Newton-John Cancer Centre
3128 - Box Hill - Box Hill Hospital - Eastern Health
3168 - Clayton - Monash Medical Centre
3181 - Prahran - The Alfred Hospital
QLD
4006 - Herston - The Royal Brisbane and Women's Hospital Cancer Centre
SA
5000 - Adelaide - Royal Adelaide Hospital - Adelaide Cancer Centre
WA
6009 - Nedlands - Sir Charles Gairdner Hospital - WA Cancer Centre
NCT03363867
Advanced
Phase 2
Unknown
BEACON
- A Phase II Study of Bevacizumab, Atezolizumab and Cobimetinib in Patients With Recurrent Platinum Resistant High Grade Serous Ovarian Cancer
MEK inhibitor
anti-PD-L1 monoclonal antibody
Fallopian tube cancer
NOT Ovarian carcinosarcoma
NOT Ovarian clear cell carcinoma
NOT Ovarian mucinous carcinoma
Ovarian cancer
Primary peritoneal serous carcinoma
VIC
3000 - Melbourne - Peter MacCallum Cancer Centre
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Recruitment Status
Recruiting (7)
Unknown (2)
Recruitment Country and State
VIC (7)
NSW (5)
SA (4)
QLD (4)
WA (3)
NZ (1)
Phase
Phase 1 (3)
Phase 1 / Phase 2 (1)
Phase 2 (2)
Phase 3 (1)
Phase 4 (2)
Trial Type
Advanced (8)
Paed (1)
Cancer Therapy Class
MEK
100%
BRAF
67%
RAF
67%
BRAF V600
33%
CRAF
22%
pan-RAF
22%
ERBB2
11%
HRAS
11%
HRAS G12C
11%
KRAS
11%
KRAS G12C
11%
NRAS
11%
NRAS G12C
11%
PI3Kalpha
11%
FAK
11%
oestrogen axis
11%
CDK4
11%
CDK6
11%
EGFR
11%
ALK
11%
MET
11%
PKC
11%
ROS1
11%
PD-1/PD-L1
11%
PD-L1
11%
VEGF
11%
Facility
3000 - Melbourne - Peter MacCallum Cancer Centre (5)
5000 - Adelaide - Royal Adelaide Hospital - Adelaide Cancer Centre (3)
2010 - Darlinghurst - St Vincent's Hospital Sydney - The Kinghorn Cancer Centre (2)
6009 - Nedlands - Sir Charles Gairdner Hospital - WA Cancer Centre (2)
6009 - Nedlands - Linear Clinical Research (1)
2031 - Randwick - Scientia Clinical Research Ltd (1)
3144 - Malvern - Cabrini Health, Cabrini Cancer Care Centre (1)
4120 - Greenslopes - Greenslopes Private Hospital (1)
5042 - Bedford Park - Southern Oncology Clinical Research Unit (1)
2031 - Randwick - Prince of Wales Hospital (1)
4066 - Auchenflower - Icon Cancer Centre at Wesley Hospital (1)
NZ.1023 - Grafton - Auckland City Hospital - Cancer & Blood Research (1)
3004 - Melbourne, Southbank - Alfred Health (1)
3052 - Parkville - Royal Children's Hospital Melbourne (1)
2145 - Westmead - The Crown Princess Mary Cancer Centre - Westmead Hospital (1)
4102 - Woolloongabba - Princess Alexandra Hospital (1)
2065 - St Leonards - Northern Sydney Cancer Centre, Royal North Shore Hospital (1)
3084 - Heidelberg - Austin Hospital Olivia Newton-John Cancer Centre (1)
3128 - Box Hill - Box Hill Hospital - Eastern Health (1)
3168 - Clayton - Monash Medical Centre (1)
3181 - Prahran - The Alfred Hospital (1)
4006 - Herston - The Royal Brisbane and Women's Hospital Cancer Centre (1)
Cancer Type
Cancer
Solid tumour
Central nervous system cancer
Glioma
Melanoma
Neurological cancer
Lung cancer
Non-small cell lung cancer
Respiratory tract cancer
Thoracic cancer
Gynaecological cancer
Ovarian cancer
Endocrine gland cancer
High-grade glioma
Low-grade glioma
Malignant glioma
Thyroid cancer
Epithelial Ovarian Cancer
Low-grade serous ovarian cancer
Ovarian adenocarcinoma
Ovarian serous carcinoma
Differentiated thyroid carcinoma
Anaplastic astrocytoma
Anaplastic ganglioglioma
Anaplastic oligodendroglioma
Anaplastic pleomorphic xanthoastrocytoma
Astrocytoma
Benign glioma
Central neurocytoma
Desmoplastic infantile astrocytoma
Diffuse astrocytoma
Extra-ventricular Neurocytoma
Gangliocytoma
Ganglioglioma
Glioblastoma
Glioneuronal tumour
Liponeurocytoma
Neuroblastic tumour
Neurofibromatosis
Oligodendroglioma
Papillary glioneuronal tumour
Peripheral nervous system tumour
Pilocytic astrocytoma
Pleomorphic xanthoastrocytoma
Rosette-forming glioneuronal tumour
Colorectal cancer
Cutaneous melanoma
Gastrointestinal cancer
Lower gastrointestinal cancer
Skin cancer
Uveal melanoma
Fallopian tube cancer
High-grade serous carcinoma of the ovary, fallopian tube, and peritoneum
Peritoneal cancer
Primary peritoneal serous carcinoma
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