ARTICANZ - Beta (ver 0.91)
Annotated Registry of Trials in Cancer, Australia and New Zealand Ed.
- Results - target/PI3K-alpha-RAS-breaker
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Search results
target/PI3K-alpha-RAS-breaker
3
trial(s) found.
NCT06917079
Advanced
Phase 1
Recruiting
A Phase 1a/1b Open-Label Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of BBO-11818 in Subjects With Advanced KRAS Mutant Cancers (
TBBO11818-101
)
BBO-10203
Carboplatin
Cetuximab
Cisplatin
Gemcitabine
Nab-paclitaxel
PI3K alpha-RAS breaker
Pembrolizumab
Pemetrexed
anti-EGFR monoclonal antibody
anti-PD-1 monoclonal antibody
antimetabolite
cancer therapy
cancer therapy,EGFR-targeting
cancer therapy,PD-1-targeting
cancer therapy,PD-1/PD-L1-targeting
cancer therapy,PI3Kalpha-targeting
cytotoxic chemotherapy
immune checkpoint blockade
immune checkpoint blockade,PD-1-targeting
immuno-oncology therapy,EGFR-targeting
immuno-oncology therapy,PD-1-targeting
platinum-based antineoplastic agent
taxane
+ PI3K alpha-RAS breaker
Cancer
Colorectal cancer
Lung cancer
Non-small cell lung cancer
Pancreatic adenocarcinoma
Solid tumour
VIC
3000 - Melbourne - Peter MacCallum Cancer Centre
NCT06625775
Advanced
Phase 1
Recruiting
A Phase 1a/1b Open-Label Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of BBO-10203 in Subjects With Advanced Solid Tumors (The BREAKER-101 Study) (
TBBO10203-101
)
PI3K alpha-RAS breaker
Breast cancer
Colorectal cancer
HER2-negative breast cancer
HER2-positive breast cancer
Non-small cell lung cancer
RAS-mutant colorectal cancer
NSW
2031 - Randwick - Scientia Clinical Research Ltd
VIC
3000 - Melbourne - Peter MacCallum Cancer Centre
NCT06343402
Advanced
Phase 1
Recruiting
A Phase 1a/1b Open-Label Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of BBO-8520 in Subjects With Advanced KRASG12C Mutant Non-Small Cell Lung Cancer - The ONKORAS-101 Study (
TBBO8520-101
)
KRAS G12C inhibitor
+ PI3K alpha-RAS breaker
Colorectal adenocarcinoma
Non-small cell lung cancer
NSW
2010 - Darlinghurst - St Vincent's Hospital Sydney - The Kinghorn Cancer Centre
VIC
3000 - Melbourne - Peter MacCallum Cancer Centre
3199 - Frankston - Peninsula Health Frankston Hospital
SA
5011 - Woodville South - The Queen Elizabeth Hospital
5042 - Bedford Park - Flinders Medical Centre
WA
6009 - Nedlands - Linear Clinical Research
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Recruitment Status
Recruiting (3)
Recruitment Country and State
VIC (3)
NSW (2)
SA (1)
WA (1)
Phase
Phase 1 (3)
Trial Type
Advanced (3)
Cancer Therapy Class
PI3Kalpha
100%
PD-1
67%
PD-1/PD-L1
67%
EGFR
33%
CDK4
33%
CDK6
33%
ERBB2
33%
ER
33%
VEGF
33%
oestrogen axis
33%
DPD
33%
KRAS
33%
KRAS G12C
33%
orotate phosphoribosyltransferase
33%
Facility
3000 - Melbourne - Peter MacCallum Cancer Centre (3)
2031 - Randwick - Scientia Clinical Research Ltd (1)
2010 - Darlinghurst - St Vincent's Hospital Sydney - The Kinghorn Cancer Centre (1)
3199 - Frankston - Peninsula Health Frankston Hospital (1)
5011 - Woodville South - The Queen Elizabeth Hospital (1)
5042 - Bedford Park - Flinders Medical Centre (1)
6009 - Nedlands - Linear Clinical Research (1)
Cancer Type
Cancer
Colorectal cancer
Gastrointestinal cancer
Lower gastrointestinal cancer
Lung cancer
Non-small cell lung cancer
Respiratory tract cancer
Solid tumour
Thoracic cancer
Colorectal adenocarcinoma
Exocrine pancreatic cancer
Pancreatic adenocarcinoma
Pancreatic cancer
Pancreatobiliary cancer
Upper gastrointestinal cancer
Breast adenocarcinoma
Breast cancer
HER2-negative breast cancer
HER2-positive breast cancer
RAS-mutant colorectal cancer
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