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Annotated Registry of Trials in Cancer, Australia and New Zealand Ed.
- Results - target/PI3K-alpha-inhibitor-allosteric-mutant-selective
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ARTICANZ provides informational content about cancer drug trials in Australia/NZ that is updated weekly but may not be completely accurate, and should not replace medical advice from qualified healthcare professionals. The platform is intended to be useful, providing information "as is" without warranties. Non-medical users must always consult healthcare providers for all clinical decisions.
Search results
target/PI3K-alpha-inhibitor-allosteric-mutant-selective
3
trial(s) found.
NCT06982521
Advanced
Phase 3
Recruiting
A Phase 3 Open-Label Randomized Study Assessing the Efficacy and Safety of RLY-2608 + Fulvestrant Versus Capivasertib + Fulvestrant as Treatment for PIK3CA-mutant Hormone Receptor Positive, Human Epidermal Growth Factor Receptor 2 Negative (HR+/HER2-) Locally Advanced or Metastatic Breast Cancer Following Recurrence or Progression On or After Treatment With a CDK4/6 Inhibitor (
ReDiscover-2
)
PI3K alpha inhibitor,allosteric,mutant-selective
pan-AKT inhibitor
selective estrogen receptor degrader
Breast cancer
Cancer
HER2-negative breast cancer
NSW
2010 - Darlinghurst - St Vincent's Hospital Sydney - The Kinghorn Cancer Centre
2076 - Wahroonga - Sydney Adventist Hospital
VIC
3000 - Melbourne - Peter MacCallum Cancer Centre
3004 - Melbourne, Southbank - Alfred Health
3021 - St Albans - Western Health - Sunshine Hospital
3220 - Geelong - Andrew Love Cancer Centre, University Hospital Geelong
3355 - Wendouree - Ballarat Oncology & Haematology Clinical Trials Unit
NCT06736704
Advanced
Phase 1 / Phase 2
Recruiting
A Phase 1/2, Open-Label Dose Escalation and Expansion Study of SNV4818 as Monotherapy or in Combination With Other Anticancer Agents in Participants With Advanced Solid Tumors (
SNV4818-101
)
PI3K alpha inhibitor,allosteric,mutant-selective
Breast cancer
Endometrial cancer
HPV-related cancer
Ovarian cancer
NSW
2031 - Randwick - Scientia Clinical Research Ltd
2050 - Camperdown - Chris O'Brien Lifehouse
VIC
3000 - Melbourne - Peter MacCallum Cancer Centre
3168 - Clayton - Monash Medical Centre
WA
6009 - Nedlands - Linear Clinical Research
NCT05216432
Advanced
Phase 1
Recruiting
First-in-Human Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, as a Single Agent in Patients With Advanced Solid Tumors and in Combination With Endocrine Therapy +/- a CDK4/6 or CDK4 Inhibitor in Patients With Advanced Solid Tumors or Advanced Breast Cancer (
RLY-2608-101
)
PI3K alpha inhibitor,allosteric,mutant-selective
Breast cancer
HER2-negative breast cancer
NSW
2010 - Darlinghurst - St Vincent's Hospital Sydney - The Kinghorn Cancer Centre
VIC
3000 - Melbourne - Peter MacCallum Cancer Centre
3004 - Melbourne, Southbank - Alfred Health
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Recruitment Status
Recruiting (3)
Recruitment Country and State
NSW (3)
VIC (3)
WA (1)
Phase
Phase 1 (1)
Phase 1 / Phase 2 (1)
Phase 3 (1)
Trial Type
Advanced (3)
Cancer Therapy Class
ER
100%
PI3Kalpha
100%
oestrogen axis
100%
CDK4
67%
CDK6
67%
AKT
33%
CDK4 selective
33%
Facility
3000 - Melbourne - Peter MacCallum Cancer Centre (3)
2010 - Darlinghurst - St Vincent's Hospital Sydney - The Kinghorn Cancer Centre (2)
3004 - Melbourne, Southbank - Alfred Health (2)
2076 - Wahroonga - Sydney Adventist Hospital (1)
3021 - St Albans - Western Health - Sunshine Hospital (1)
3220 - Geelong - Andrew Love Cancer Centre, University Hospital Geelong (1)
3355 - Wendouree - Ballarat Oncology & Haematology Clinical Trials Unit (1)
2031 - Randwick - Scientia Clinical Research Ltd (1)
2050 - Camperdown - Chris O'Brien Lifehouse (1)
3168 - Clayton - Monash Medical Centre (1)
6009 - Nedlands - Linear Clinical Research (1)
Cancer Type
Breast cancer
Cancer
Solid tumour
Breast adenocarcinoma
HER2-negative breast cancer
Endometrial cancer
Gynaecological cancer
HPV-related cancer
Ovarian cancer
Viral-related cancer
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