ARTICANZ - Beta (ver 0.91)
Annotated Registry of Trials in Cancer, Australia and New Zealand Ed.
- Results - target/anti-ERBB3-antibody-drug-conjugate
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ARTICANZ provides informational content about cancer drug trials in Australia/NZ that is updated weekly but may not be completely accurate, and should not replace medical advice from qualified healthcare professionals. The platform is intended to be useful, providing information "as is" without warranties. Non-medical users must always consult healthcare providers for all clinical decisions.
Search results
target/anti-ERBB3-antibody-drug-conjugate
10
trial(s) found.
NCT07111520
Advanced
Phase 1 / Phase 2
Recruiting
A Phase Ib/II, Multi-site, Open-label, Dose Finding Trial to Evaluate the Safety, Efficacy, and Pharmacokinetics of BNT326 in Combination With BNT327 in Participants With Advanced Non-small Cell Lung Cancer (NSCLC) (
BNT326-02
)
anti-ERBB3 antibody-drug conjugate
bispecific PD-L1/VEGFA antibody
Non-small cell lung cancer
NSW
2065 - St Leonards - Northern Sydney Cancer Centre, Royal North Shore Hospital
2145 - Westmead - The Crown Princess Mary Cancer Centre - Westmead Hospital
2217 - Kogarah - St George Private Hospital
QLD
4101 - South Brisbane - Mater Hospital Brisbane / ICON Cancer Centre
4224 - Tugun - Genesis Care Tugun - John Flynn Private Hospital
SA
5000 - Adelaide - Cancer Research SA
NCT07070232
Advanced
Phase 1 / Phase 2
Recruiting
A Phase I/II, Open-label, Adaptive Two-part Trial to Evaluate the Safety, Efficacy, Optimal Dose and Pharmacokinetics of BNT326 as Monotherapy and in Combination With Cancer Immunotherapies in Participants With Advanced Solid Tumors (
BNT326-01
)
anti-ERBB3 antibody-drug conjugate
Breast cancer
Cervical cancer
Colorectal adenocarcinoma
Gastroesophageal junction adenocarcinoma
Melanoma
Mucosal melanoma
Non-small cell lung cancer
Solid tumour
Uveal melanoma
NSW
2010 - Darlinghurst - St Vincent's Hospital Sydney - The Kinghorn Cancer Centre
2065 - Wollstonecraft - Melanoma Institute Australia - The Poche Centre
2148 - Blacktown - Blacktown Hospital, Blacktown Cancer and Haematology Centre
VIC
3004 - Melbourne, Southbank - Alfred Health
3084 - Heidelberg - Austin Hospital Olivia Newton-John Cancer Centre
3199 - Frankston - Peninsula Health Frankston Hospital
QLD
4215 - Southport - Tasman Oncology
SA
5000 - Adelaide - Cancer Research SA
WA
6009 - Nedlands - One Clinical Research
NCT07060807
Paed
Phase 3
Recruiting
An Open-label, Randomized, Phase 3 Study to Evaluate Patritumab Deruxtecan Monotherapy Versus Treatment of Physician's Choice in Hormone Receptor-positive, HER2-negative Unresectable Locally Advanced or Metastatic Breast Cancer (HERTHENA-Breast04). (
1022-016
)
anti-ERBB3 antibody-drug conjugate
Breast cancer
NSW
2050 - Camperdown - Chris O'Brien Lifehouse
2148 - Blacktown - Blacktown Hospital, Blacktown Cancer and Haematology Centre
VIC
3004 - Melbourne, Southbank - Alfred Health
3168 - Clayton - Monash Medical Centre
WA
6009 - Nedlands - Sir Charles Gairdner Hospital - WA Cancer Centre
NCT06956690
Advanced
Phase 1 / Phase 2
Recruiting
A First-in-Human, Open-label, Phase 1/2 Clinical Trial to Assess the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of HMBD-501 in Patients With Advanced-Stage, Relapsed/Refractory HER3-Expressing Solid Tumors (
HMBD-501-101
)
anti-ERBB3 antibody-drug conjugate
Breast cancer
Melanoma
Non-small cell lung cancer
NSW
2228 - Miranda - Southside Cancer Care Centre
2560 - Campbelltown - Macarthur Cancer Therapy Centre - Campbelltown Hospital
NCT06941272
Paed
Phase 1 / Phase 2
Recruiting
LIGHTBEAM-U01 Substudy 01C: A Phase 1/2 Substudy to Evaluate the Safety and Efficacy of Patritumab Deruxtecan in Pediatric Participants With Relapsed or Refractory Solid Tumors (
9999-01C
)
anti-ERBB3 antibody-drug conjugate
Cancer
NSW
2031 - Randwick - Sydney Children's Hospital
VIC
3052 - Parkville - Royal Children's Hospital Melbourne
QLD
4101 - South Brisbane - Queensland Children's Hospital
NCT06730386
Advanced
Phase 1
Recruiting
A First-in-human, Phase I Study of Evaluating Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of AK138D1 in the Treatment of Advanced Solid Tumors (
AK138D1-101
)
anti-ERBB3 antibody-drug conjugate
Solid tumour
NSW
2109 - North Ryde - Macquarie University Hospital
2148 - Blacktown - Blacktown Hospital, Blacktown Cancer and Haematology Centre
VIC
3199 - Frankston - Peninsula Health Frankston Hospital
QLD
4101 - South Brisbane - Mater Hospital Brisbane / ICON Cancer Centre
NCT06596694
Advanced
Phase 1 / Phase 2
Recruiting
A Phase 1/2 Study to Evaluate the Safety and Efficacy of Patritumab Deruxtecan in Gastrointestinal Cancers (
1022-011
)
anti-ERBB3 antibody-drug conjugate
Gastrointestinal cancer
NSW
2145 - Westmead - The Crown Princess Mary Cancer Centre - Westmead Hospital
VIC
3004 - Melbourne, Southbank - Alfred Health
3084 - Heidelberg - Austin Hospital Olivia Newton-John Cancer Centre
WA
6009 - Nedlands - Sir Charles Gairdner Hospital - WA Cancer Centre
NZ
NZ.1023 - Grafton - Auckland City Hospital - Cancer & Blood Research
NCT06220864
Advanced
Phase 1
Recruiting
A Phase 1, Open-Label Dose Escalation and Expansion Study of SNV1521 in Participants With Advanced Solid Tumors (
SNV1521-101
)
PARP1-selective inhibitor
+ anti-ERBB3 antibody-drug conjugate
Prostate cancer
NSW
2031 - Randwick - Scientia Clinical Research Ltd
VIC
3004 - Melbourne, Southbank - Alfred Health
3168 - Clayton - Monash Medical Centre
QLD
4102 - Woolloongabba - Princess Alexandra Hospital
WA
6009 - Nedlands - Linear Clinical Research
NCT06172478
Advanced
Phase 2
Recruiting
HERTHENA-PanTumor01 (
U31402-277
): A Phase 2, Multicenter, Multicohort, Open-Label, Proof of Concept Study of Patritumab Deruxtecan (HER3-DXd; U3-1402) in Subjects With Locally Advanced or Metastatic Solid Tumors
anti-ERBB3 antibody-drug conjugate
Bladder cancer
Cervical cancer
Endometrial cancer
Gastric cancer
Gastroesophageal cancer
Head and neck squamous cell carcinoma
High-grade serous ovarian cancer
Melanoma
Oesophageal cancer
Pancreatic adenocarcinoma
Prostate adenocarcinoma
NSW
2050 - Camperdown - Chris O'Brien Lifehouse
VIC
3168 - Clayton - Monash Medical Centre
QLD
4032 - Chermside - Icon Cancer Care Chermside
4812 - Hyde Park - Icon Cancer Centre Townsville
TAS
7000 - Hobart - ICON Cancer Care Hobart
NCT06199908
Advanced
Phase 1
Unknown
First-in-Human, Phase 1 Study of AMT-562 in Patients With Advanced Solid Tumors (
AMT-562-01
)
anti-ERBB3 antibody-drug conjugate
Solid tumour
NSW
2109 - North Ryde - Macquarie University Hospital
VIC
3144 - Malvern - Cabrini Health, Cabrini Cancer Care Centre
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Recruitment Status
Recruiting (9)
Unknown (1)
Recruitment Country and State
NSW (10)
VIC (8)
QLD (6)
WA (4)
SA (2)
NZ (1)
TAS (1)
Phase
Phase 1 (3)
Phase 1 / Phase 2 (5)
Phase 2 (1)
Phase 3 (1)
Trial Type
Advanced (8)
Paed (2)
Cancer Therapy Class
ERBB3
100%
PD-1/PD-L1
20%
PD-L1
20%
VEGFA
20%
SMO
10%
ERBB2
10%
AR
10%
CYP17A1
10%
PARP
10%
PARP1-selective
10%
androgen axis
10%
Facility
3004 - Melbourne, Southbank - Alfred Health (4)
2148 - Blacktown - Blacktown Hospital, Blacktown Cancer and Haematology Centre (3)
3168 - Clayton - Monash Medical Centre (3)
2145 - Westmead - The Crown Princess Mary Cancer Centre - Westmead Hospital (2)
4101 - South Brisbane - Mater Hospital Brisbane / ICON Cancer Centre (2)
5000 - Adelaide - Cancer Research SA (2)
3084 - Heidelberg - Austin Hospital Olivia Newton-John Cancer Centre (2)
3199 - Frankston - Peninsula Health Frankston Hospital (2)
2050 - Camperdown - Chris O'Brien Lifehouse (2)
6009 - Nedlands - Sir Charles Gairdner Hospital - WA Cancer Centre (2)
2109 - North Ryde - Macquarie University Hospital (2)
2065 - St Leonards - Northern Sydney Cancer Centre, Royal North Shore Hospital (1)
2217 - Kogarah - St George Private Hospital (1)
4224 - Tugun - Genesis Care Tugun - John Flynn Private Hospital (1)
2010 - Darlinghurst - St Vincent's Hospital Sydney - The Kinghorn Cancer Centre (1)
2065 - Wollstonecraft - Melanoma Institute Australia - The Poche Centre (1)
4215 - Southport - Tasman Oncology (1)
6009 - Nedlands - One Clinical Research (1)
2228 - Miranda - Southside Cancer Care Centre (1)
2560 - Campbelltown - Macarthur Cancer Therapy Centre - Campbelltown Hospital (1)
2031 - Randwick - Sydney Children's Hospital (1)
3052 - Parkville - Royal Children's Hospital Melbourne (1)
4101 - South Brisbane - Queensland Children's Hospital (1)
NZ.1023 - Grafton - Auckland City Hospital - Cancer & Blood Research (1)
2031 - Randwick - Scientia Clinical Research Ltd (1)
4102 - Woolloongabba - Princess Alexandra Hospital (1)
6009 - Nedlands - Linear Clinical Research (1)
4032 - Chermside - Icon Cancer Care Chermside (1)
4812 - Hyde Park - Icon Cancer Centre Townsville (1)
7000 - Hobart - ICON Cancer Care Hobart (1)
3144 - Malvern - Cabrini Health, Cabrini Cancer Care Centre (1)
Cancer Type
Cancer
Solid tumour
Thoracic cancer
Lung cancer
Non-small cell lung cancer
Respiratory tract cancer
Breast cancer
Gastrointestinal cancer
Melanoma
Cervical cancer
Gastric cancer
Gastroesophageal cancer
Gynaecological cancer
HPV-related cancer
HPV16-positive cancer
Oesophageal cancer
Upper gastrointestinal cancer
Viral-related cancer
Male genital cancers
Prostate cancer
Urogenital cancer
Colorectal adenocarcinoma
Colorectal cancer
Gastric carcinoma
Gastroesophageal junction adenocarcinoma
Lower gastrointestinal cancer
Mucosal melanoma
Uveal melanoma
Bladder cancer
Endometrial cancer
Epithelial Ovarian Cancer
Exocrine pancreatic cancer
Head and neck cancer
Head and neck squamous cell carcinoma
High-grade serous carcinoma of the ovary, fallopian tube, and peritoneum
High-grade serous ovarian cancer
Ovarian adenocarcinoma
Ovarian cancer
Ovarian serous carcinoma
Pancreatic adenocarcinoma
Pancreatic cancer
Pancreatobiliary cancer
Prostate adenocarcinoma
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