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Annotated Registry of Trials in Cancer, Australia and New Zealand Ed.
- Results - target/anti-NECTIN4-antibody-drug-conjugate
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ARTICANZ provides informational content about cancer drug trials in Australia/NZ that is updated weekly but may not be completely accurate, and should not replace medical advice from qualified healthcare professionals. The platform is intended to be useful, providing information "as is" without warranties. Non-medical users must always consult healthcare providers for all clinical decisions.
Search results
target/anti-NECTIN4-antibody-drug-conjugate
4
trial(s) found.
NCT07218380
Advanced
Phase 3
Recruiting
FORAGER-2
: A Phase 3, Randomized, Double-blind, Placebo-controlled Study Evaluating the Efficacy and Safety of Vepugratinib Combined With Enfortumab Vedotin and Pembrolizumab in Adults With Untreated Locally Advanced or Metastatic Urothelial Carcinoma With an FGFR3 Genetic Alteration
FGFR3 inhibitor
anti-NECTIN4 antibody-drug conjugate
anti-PD-1 monoclonal antibody
placebo
Bladder cancer
Cancer
Carcinoma
NSW
2031 - Randwick - Prince of Wales Hospital
2109 - North Ryde - Macquarie University Hospital
2298 - Waratah - Calvary Mater Newcastle Medical Oncology
VIC
3021 - St Albans - Western Health - Sunshine Hospital
3084 - Heidelberg - Austin Hospital Olivia Newton-John Cancer Centre
3128 - Box Hill - Box Hill Hospital - Eastern Health
QLD
4101 - South Brisbane - Mater Hospital Brisbane / ICON Cancer Centre
WA
6009 - Nedlands - Sir Charles Gairdner Hospital - WA Cancer Centre
NCT06465069
Advanced
Phase 1
Recruiting
A Phase 1a/1b Study of LY4052031, an Antibody-Drug Conjugate Targeting Nectin-4, in Participants With Advanced or Metastatic Urothelial Carcinoma or Other Solid Tumors (
NEXUS-01
)
anti-NECTIN4 antibody-drug conjugate
Bladder cancer
Cervical cancer
Head and neck squamous cell carcinoma
Non-small cell lung cancer
Oesophageal cancer
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal pelvis cancer
Solid tumour
Triple-negative breast cancer
NSW
2010 - Darlinghurst - St Vincent's Hospital Sydney - The Kinghorn Cancer Centre
WA
6009 - Nedlands - Linear Clinical Research
NCT06238479
Advanced
Phase 1
Recruiting
A Phase 1 Trial Investigating LY4101174, an Antibody-Drug Conjugate Targeting Nectin-4, in Participants With Recurrent, Advanced or Metastatic Solid Tumors (
EXCEED
)
anti-NECTIN4 antibody-drug conjugate
Bladder cancer
Cervical cancer
Head and neck squamous cell carcinoma
Non-small cell lung cancer
Oesophageal cancer
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal pelvis cancer
Solid tumour
Triple-negative breast cancer
VIC
3084 - Heidelberg - Austin Hospital Olivia Newton-John Cancer Centre
SA
5037 - Kurralta Park - Icon Cancer Centre Adelaide
NCT05614739
Advanced
Phase 1
Recruiting
FORAGER-1
: A Phase 1, Open-Label, Multicenter Study of LOXO-435 (LY3866288) in Locally Advanced or Metastatic Solid Tumors Including Urothelial Cancer With FGFR3 Alterations
FGFR3 inhibitor
+ anti-NECTIN4 antibody-drug conjugate
Bladder cancer
Cancer
NSW
2010 - Darlinghurst - St Vincent's Hospital Sydney - The Kinghorn Cancer Centre
2065 - St Leonards - GenesisCare North Shore Private Hospital
2109 - North Ryde - Macquarie University Hospital
2298 - Waratah - Calvary Mater Newcastle Medical Oncology
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Recruitment Status
Recruiting (4)
Recruitment Country and State
NSW (3)
VIC (2)
WA (2)
QLD (1)
SA (1)
Phase
Phase 1 (3)
Phase 3 (1)
Trial Type
Advanced (4)
Cancer Therapy Class
Nectin4
100%
FGFR3
50%
PD-1
50%
PD-1/PD-L1
50%
Facility
2109 - North Ryde - Macquarie University Hospital (2)
2298 - Waratah - Calvary Mater Newcastle Medical Oncology (2)
3084 - Heidelberg - Austin Hospital Olivia Newton-John Cancer Centre (2)
2010 - Darlinghurst - St Vincent's Hospital Sydney - The Kinghorn Cancer Centre (2)
2031 - Randwick - Prince of Wales Hospital (1)
3021 - St Albans - Western Health - Sunshine Hospital (1)
3128 - Box Hill - Box Hill Hospital - Eastern Health (1)
4101 - South Brisbane - Mater Hospital Brisbane / ICON Cancer Centre (1)
6009 - Nedlands - Sir Charles Gairdner Hospital - WA Cancer Centre (1)
6009 - Nedlands - Linear Clinical Research (1)
5037 - Kurralta Park - Icon Cancer Centre Adelaide (1)
2065 - St Leonards - GenesisCare North Shore Private Hospital (1)
Cancer Type
Bladder cancer
Cancer
Solid tumour
Urogenital cancer
Breast adenocarcinoma
Breast cancer
Cervical cancer
Gastroesophageal cancer
Gastrointestinal cancer
Gynaecological cancer
HPV-related cancer
HPV16-positive cancer
Head and neck cancer
Head and neck squamous cell carcinoma
Lung cancer
Male genital cancers
Non-small cell lung cancer
Oesophageal cancer
Ovarian cancer
Pancreatic cancer
Pancreatobiliary cancer
Prostate cancer
Renal pelvis cancer
Respiratory tract cancer
Thoracic cancer
Triple-negative breast cancer
Upper gastrointestinal cancer
Viral-related cancer
Carcinoma
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